健康人和脑卒中患者视觉反馈步行训练后脑激活特征的功能性近红外光谱技术研究

doi:10.3969/j.issn.1006-9771.2024.09.011

Abstract

Abstract:

Objective To compare the cortical activation characteristic in the healthy subjects and hemiplegia patients during executing treadmill walking with visual feedback (TWVF).
Methods From August to November, 2021, eight stroke patients with right hemiplegia (patient group) and eight healthy subjects (healthy group) in Fifth Hospital of Xiamen were recruited. Both groups wore functional near-infrared spectroscopy (fNIRS) caps and executed TWVF, respectively. Experimental block design for walking modes included the preparation period (10 s) and task period (five cycles of "step 30 s- rest 30 s"). The cortical activation (β values) were measured. The regions of interest (ROI) included the pre-motor cortex (PMC), supplementary motor area (SMA), primary motor cortex (M1), primary somatosensory cortex (S1) and sensorimotor cortex (SMC, M1+S1).
Results No activation in bilateral M1, and some significant activation (P < 0.05) in the left hemisphere SAM, PMC and S1, were found during walking in the healthy group. M1 was activated more in the unaffected (right) hemisphere than in the affected (left) hemisphere during walking in the patient group (P < 0.05), and less PMC activation was found (P < 0.05). M1 in bilateral hemispheres, SMA in the unaffected hemisphere and PMC in the affected hemisphere were activated more in the patient group than in the healthy group (P < 0.05).
Conclusion The locomotor network of SMC-PMC-SMA are activated more in the hemiplegic patients than in the healthy pepole during walking. M1 are almost not activated in the healthy people during walking, and compensatorily activated in M1 of the unaffected side in the hemiplegic patients.

Key words: stroke, walking, brain activation, functional near infrared spectroscopy

CLC Number:

R743.3

XIE Dandan, CHEN Shanjia, LEI Lei, YU Guo, YU Jiahui, ZHAO Jiapei, HE Xiaokuo. Characteristics of brain activation during treadmill walking with visual feedback in healthy subjects and hemiplegic patients: a functional near infrared spectroscopy study[J]. Chinese Journal of Rehabilitation Theory and Practice, 2024, 30(9): 1074-1081.

Figures/Tables 4

Table 1

Figure 1

Table 2

List of group-level channel activation in brain (β value)"

CH	健康组	患者组	健康组内比较		患者组内比较		两组间对比
CH	健康组	患者组	t值	P值	t值	P值	t值	P值
1	-0.020±0.026	-0.171±0.113	-0.773	0.465	-1.514	0.190	-1.487	0.163
2	-0.041±0.033	-0.012±0.036	-1.238	0.256	-0.338	0.749	0.582	0.571
3	0.052±0.074	-0.173±0.105	0.700	0.507	-1.646	0.161	-1.805	0.096
4	0.053±0.075	-0.219±0.091	0.705	0.504	-2.424	0.060	-2.334	0.038
5	0.018±0.022	-0.094±0.046	0.819	0.440	-2.036	0.097	-2.379	0.035
6	0.017±0.023	-0.173±0.085	0.744	0.481	-2.029	0.098	-2.449	0.031
7	0.017±0.016	-0.140±0.069	1.045	0.331	-2.023	0.099	-2.529	0.026
8	0.013±0.052	0.254±0.067	0.257	0.805	3.800	0.013	2.879	0.014
9	-0.119±0.132	-0.152±0.051	-0.903	0.396	-2.989	0.030	-0.203	0.842
10	0.107±0.080	0.114±0.008	1.333	0.224	14.052	< 0.001	0.075	0.941
11	0.020±0.037	0.014±0.005	0.538	0.607	2.900	0.034	-0.134	0.896
12	-0.150±0.134	-0.014±0.087	-1.120	0.300	-0.165	0.875	0.785	0.448
13	0.033±0.051	0.128±0.063	0.633	0.547	2.041	0.097	1.191	0.257
14	0.048±0.074	0.150±0.076	0.651	0.536	1.982	0.104	0.944	0.364
15	0.004±0.026	0.281±0.088	0.167	0.872	3.188	0.024	3.402	0.005
16	0.042±0.030	0.243±0.117	1.387	0.208	2.078	0.092	1.904	0.081
17	-0.119±0.090	0.233±0.108	-1.318	0.229	2.154	0.084	2.515	0.027
18	-0.039±0.044	-0.012±0.033	-0.894	0.401	-0.368	0.728	0.470	0.647
19	-0.009±0.022	0.098±0.051	-0.421	0.686	1.922	0.113	2.120	0.056
20	0.081±0.047	0.124±0.065	1.733	0.127	1.911	0.114	0.562	0.585
21	-0.008±0.013	-0.163±0.107	-0.656	0.532	-1.526	0.188	-1.675	0.120
22	0.165±0.081	-0.096±0.062	2.036	0.081	-1.549	0.182	-2.409	0.033
23	0.070±0.030	0.091±0.045	2.351	0.051	2.029	0.098	0.409	0.690
24	0.059±0.031	0.063±0.049	1.890	0.101	1.307	0.248	0.079	0.939
25	0.013±0.079	0.123±0.046	0.164	0.875	2.678	0.044	1.101	0.293
26	-0.007±0.017	0.084±0.026	-0.376	0.718	3.267	0.022	3.030	0.010
27	0.061±0.038	0.138±0.035	1.597	0.154	3.983	0.010	1.455	0.171
28	0.029±0.020	0.116±0.032	1.481	0.182	3.670	0.014	2.457	0.030
29	0.017±0.010	-0.214±0.112	1.673	0.138	-1.917	0.113	-2.406	0.033
30	0.014±0.017	0.091±0.036	0.780	0.461	2.522	0.053	2.102	0.057
31	0.019±0.024	0.015±0.011	0.813	0.443	1.318	0.245	-0.152	0.882
32	0.035±0.021	-0.008±0.036	1.718	0.129	-0.216	0.838	1.112	0.288
33	0.039±0.015	0.067±0.041	2.496	0.041	1.648	0.160	0.735	0.476
34	0.034±0.010	0.135±0.050	3.424	0.011	2.726	0.041	2.294	0.041
35	0.040±0.025	0.113±0.040	1.635	0.146	2.843	0.036	1.626	0.130
36	0.029±0.017	0.006±0.011	1.697	0.134	0.536	0.615	1.033	0.322
37	0.066±0.026	0.173±0.052	2.514	0.040	3.334	0.021	1.977	0.071

Table 2

Figure 2

References 30

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Brodmann分区法	通道序号
S1：BA 1,2,3 Wernicke区：BA40 Subcentral area中央下区：BA43	CH03/05/06/09/11、CH21/29/30/35/37、CH01/36 CH02/31 CH3/37
M1：BA4	CH08/10/15/16/19/20/25/26/28
PMC和SMA：BA6	CH04/07/12/13/14/17/18/22/23/24/27/32/33/34

Characteristics of brain activation during treadmill walking with visual feedback in healthy subjects and hemiplegic patients: a functional near infrared spectroscopy study

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