骶神经根磁刺激联合索利那新治疗女性难治性膀胱过度活动症的效果

doi:10.3969/j.issn.1006-9771.2020.06.019

《Chinese Journal of Rehabilitation Theory and Practice》 ›› 2020, Vol. 26 ›› Issue (6): 725-729.doi: 10.3969/j.issn.1006-9771.2020.06.019

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Effects of Sacral Nerve Root Magnetic Stimulation Combined with Solifenacin on Refractory Overactive Bladder in Women

ZHU Wen-jing¹,LÜ Jian-wei²(),LÜ Ting-ting²,SONG Xu³

1. Department of Urology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
2. Department of Urology, South Campus of Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201112, China
3. Department of Urology, the Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China

Received:2019-12-24 Revised:2020-01-26 Published:2020-06-25 Online:2020-06-29
Contact: LÜ Jian-wei E-mail:ljwass@126.com
Supported by:
Shanghai Key Specialty Cultivation Project of Traditional Chinese Medicine(Urology);Key Discipline Construction Project of Pudong Health and Family Planning Commision of Shanghai(PWZxk2017-16)

Abstract

Abstract:

Objective To investigate the clinical efficacy of sacral nerve root magnetic stimulation combined with Solifenacin in women with refractory overactive bladder (OAB).Methods From January to December, 2017, 120 women with refractory OAB were randomly divided into sacral nerve root magnetic stimulation group (group A, n = 40), Solifenacin group (group B, n = 40), and combined treatment group (group C, n = 40). Before and after treatment, they were assessed with the urine diary (number of daily urination, number of nightly urination, single urine output, number of urgent urination), urodynamic index (initial urinary bladder capacity, maximum bladder capacity) and Overactive Bladder Symptom Score (OABSS).Results Two patients from group A, one from group B and one from group C were dropped out. The number of daily urination, the number of nightly urination, the single urine output, the number of urgent urination, the initial urinary bladder capacity and maximum bladder capacity, and OABSS were better in group C than in groups A and B (P < 0.05). Conclusion Sacral nerve root magnetic stimulation combined with Solifenacin is effective and better than anyone alone on women with refractory OAB.

Key words: refractory overactive bladder, sacral nerve root magnetic stimulation, Solifenacin

CLC Number:

R454.1

ZHU Wen-jing,LÜ Jian-wei,LÜ Ting-ting,SONG Xu. Effects of Sacral Nerve Root Magnetic Stimulation Combined with Solifenacin on Refractory Overactive Bladder in Women[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(6): 725-729.

Figures/Tables 4

References 21

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组别	n	年龄(岁)	病程(月)
骶神经根磁刺激组	40	48.25±19.11	36.57±13.46
索利那新组	40	47.34±18.76	37.41±14.83
联合治疗组	40	49.06±20.83	35.03±12.94
F值		0.31	0.11
P值		0.74	0.90

组别	n	日间排尿次数(n)		夜间排尿次数(n)		单次排尿量(ml)		尿急次数(n)
组别	n	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
骶神经根磁刺激组	38	17.56±5.64	8.56±1.73	8.11±2.42	4.37±1.87	73.76±27.07	93.14±33.27	8.33±2.57	5.14±1.46
索利那新组	39	17.33±5.70	8.78±2.09	7.89±2.52	4.45±1.94	74.24±27.56	91.43±32.61	8.10±2.79	5.05±1.75
联合治疗组	39	17.67±4.33	5.67±1.45^a	8.12±2.76	2.45±0.88^a	73.71±23.68	126.19±53.80^a	8.24±2.91	3.23±1.70^a
Z值		0.066	-2.630	1.272	-3.760	0.214	4.125	0.051	-3.007
P值		0.968	0.045	0.530	0.025	0.887	0.010	0.874	0.034

组别	n	初始尿意膀胱容量(ml)		最大膀胱容量(ml)
组别	n	治疗前	治疗后	治疗前	治疗后
骶神经根磁刺激组	38	64.33±22.91	88.91±21.10	160.67±39.09	196.52±41.62
索利那新组	39	63.71±29.43	89.28±21.16	161.79±39.31	197.47±40.84
联合治疗组	39	63.09±32.96	115.86±23.79^a	159.31±36.56	220.95±46.03^a
Z值		0.740	3.912	0.308	5.856
P值		0.691	0.017	0.827	0.009

组别	n	治疗前	治疗后
骶神经根磁刺激组	38	8.52±2.46	4.38±1.59
索利那新组	39	8.86±2.82	4.19±1.47
联合治疗组	39	8.95±2.89	2.71±0.90^a
Z值		0.779	-3.115
P值		0.678	0.030

Effects of Sacral Nerve Root Magnetic Stimulation Combined with Solifenacin on Refractory Overactive Bladder in Women

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