脊髓损伤恒河猴下肢残留跨步能力的评估

doi:10.3969/j.issn.1006-9771.2020.06.005

Abstract

Abstract:

Objective To evaluate the residual stepping ability in monkeys with spinal cord injury longitudinally.Methods Four adult female monkeys were studied. Right hemisection of 10 mm spinal cord tissue was performed at the T_7-9 segment. Gait tests of bipedal locomotion were performed before, and six weeks and twelve weeks after injury by VICON system. Gait cycle duration, amplitude of knee and ankle angles, and ratio of united parameters were obtained from successive stepping and were quantitative analyzed.Results The coordination of bilateral hindlimbs was destroyed after spinal cord injury, and the right hindlimb showed obviously dragging. The gait cycle duration of the left hindlimb increased significantly (P < 0.001), and the amplitudes of knee and ankle angle significantly increased ( P < 0.001) after spinal cord injury. The ratio of united parameters was not statistically different among all the time points ( P> 0.05). The gait cycle duration of the left hindlimb was correlated with step length (r= 0.838, P = 0.001), step height (r= 0.726, P = 0.007) and amplitude of ankle angle (r= 0.766, P = 0.004), and the amplitude of ankle angle was correlated with step length (r= 0.627, P = 0.029).Conclusion The gait pattern of monkey with spinal cord injury has been changed. The gait strategy of the uninjured side was adjusted compensatively after spinal cord injury to adapt the functional impairment of contralateral hindlimb.

Key words: Rhesus monkeys, spinal cord hemisection, gait analysis, residual stepping ability

CLC Number:

R651.2

ZHAO Can,WEI Rui-han,ZHAO Wen,JI Run,RAO Jia-sheng,YANG Zhao-yang,LI Xiao-guang. Evaluation of Residual Stepping Ability in Monkeys with Spinal Cord Injury[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(6): 648-653.

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References 22

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时间	n	步态周期
脊髓损伤前	4	1.51±0.07
脊髓损伤6周	4	2.11±0.09^a
脊髓损伤12周	4	2.06±0.09^a,b
F值		16.510
P值		< 0.001

时间	n	踝关节	膝关节
脊髓损伤前	4	33.06±1.86	37.35±1.44
脊髓损伤6周	4	46.70±2.09^a	46.70±2.09^a
脊髓损伤12周	4	46.28±2.71^a,b	52.27±1.80^a,b
F值		11.870	19.070
P值		< 0.001	< 0.001

时间	n	步长/步高	膝关节角度变化幅值/踝关节角度变化幅值
脊髓损伤前	4	9.78±1.16	1.00±0.07
脊髓损伤6周	4	12.09±1.99^a	0.92±0.10^d
脊髓损伤12周	4	8.31±1.35^b,c	0.97±0.05^e,f
F值		0.946	0.997
P值		> 0.05	> 0.05

Evaluation of Residual Stepping Ability in Monkeys with Spinal Cord Injury

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