肠内营养对缺血性脑卒中患者肠道菌群的影响

doi:10.3969/j.issn.1006-9771.2019.07.016

Abstract

Abstract: Objective To explore the effect of enteral nutrition on gut microbiota for ischemic stroke. Methods From March to April, 2017, 121 patients with convalescent ischemic stroke were enrolled. The patients received routine rehabilitation combing with 1-week enteral nutrition. The patients' fresh feces and blood samples were obtained at admission, one week and one month after the enteral nutrition, while nutritional status was assessed with Nutrition Risk Screening (NRS2002). Cytokines, including tumor necrosis factor (TNF) -α, interleukin (IL)-1α, IL-1β, IL-6 and IL-8 were tested with ELISA. Ten patients were tested with 16S rDNA Illumina HiSeq/MiSeq for gut microbiota alterations. Results The scores of NRS2002 decreased (P < 0.05), the level of serum IL-1β and IL-6 raised, while the level of IL-8 dropped one month after enteral nutrition (P < 0.05). In addition, the enteral nutrition altered the dominant bacterial community, and alleviated the diversity and species richness of bacteria, while the difference was statistically significant one week after enteral nutrition. Conclusion Enteral nutrition can alter gut microbiota to facilitate to recover ischemic stroke.

Key words: ischemic stroke, enteral nutrition, intestinal flora

CLC Number:

R743.3

FAN Chun-jiang, LIU Ting-yu, LI Gang, HUANG Jian, CAO Yang, DANG Yi-ni. Effect of Enteral Nutrition on Intestinal Flora in Patients with Ischemic Stroke[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(7): 822-827.

References

1 GoldsteinL B, BushnellC D, AdamsR J, et al. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association [J]. Stroke, 2011, 42(2): 517-584.
2 GreenA R. Pharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possibly [J]. Br J Pharmacol, 2018, 153(Suppl 1): S325-S338.
3 WangY， CuiL， JiX， et al. The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics [J]. Int J Stroke, 2011, 6(4): 355-361.
4 王少石,郑天衡,陈真理,等. 早期肠内营养治疗对急性组中近期预后的影响[J]. 中华内科杂志, 2007, 46(5): 366-369.
5 FujishimaI. Rehabilitation for swallowing disorders associated with stroke [M]. 2nd ed. Tokyo: Ishiyaku Publishers Inc., 1998.
6 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组. 中国急性缺血性脑卒中诊治指南2010[J]. 中华神经科杂志, 2010, 43(2): 146-153.
7 H P JrAdams, del ZoppoG, AlbertsM J, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists [J]. Circulation, 2007, 115(20): e478-e534.
8 BeamerN B, CoullB M, ClarkW M, et al. Interleukin-6 and interleukin-1 receptor antagonist in acute stroke [J]. Ann Neurol, 1995, 37(6): 800-805.
9 DávalosA, RicartW, Gonzalez-HuixF, et al. Effect of malnutrition after acute stroke on clinical outcome [J]. Stroke, 1996, 27(6): 1028-1032.
10 ClaessonM J, JefferyI B, CondeS, et al. Gut microbiota composition correlates with diet and health in the elderly [J]. Nature, 2012, 488(7410): 178-184.
11 GoyalM S, VenkateshS, MilbrandtJ, et al. Feeding the brain and nurturing the mind: Lingking nutrition and the gut microbiota to brain development [J]. Proc Natl Acad Sci U S A. 2015, 112(46): 14105-14112.
12 SinghV, RothS, LloveraG, et al. Microbiota dysbiosis controls the neuroinflammatory response after stroke [J]. J Neurosci, 2016, 36(28): 7428-7440.
13 KostulasN, Kivis?kkP, HuangY, et al. Ischemic stroke is associated with a systemic increase of blood mononuclear cells expressing interleukin-8 mRNA [J]. Stroke, 1998, 29(2): 462-466.
14 KimJ S. Cytokines and adhesion molecules in stroke and related diseases [J]. J Neurol Sci, 1996, 137(2): 69-78.
15 FassbenderK, RossolS, KammerT, et al. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease [J]. J Neurol Sci, 1994, 122(2): 135-139.

[1]	DENG Ting, CHEN Jingmian, LIU Xiaomeng, YAO Xiaohua, LIU Lushan, HE Wei, ZHANG Tong, LU Haitao. Risk factors of stroke-associated pneumonia for patients with mild to moderate acute ischemic stroke [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(6): 708-713.
[2]	ZHANG Chunlong, LIU Fuliang, SHANG Na, LI Fang, LIU Huizhen. Association of serum adiponectin and high sensitivity C-reactive protein levels to short-term outcome in patients with acute ischemic stroke [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(10): 1221-1226.
[3]	HAN Kaiyue,LIU Guangliang,SU Wenlong,TANG Zhiqing,ZHANG Hao. Effects of intelligent aerobic bicycle training on ischemic stroke patients at different disease courses [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(7): 822-827.
[4]	LAI Haifang,GU Lin,ZONG Ya,NIU Chuanxin,XIE Qing. Prediction of short-term outcome after subacute ischemic stroke using multiple layer perceptron neural network [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(3): 335-339.
[5]	ZHU Hui,XIA Youbing,GONG Zunke,WANG Shiyan,MA Ke,YAN Jinqiu. Effects of high-frequency repetitive transcranial magnetic stimulation on central facial paralysis after ischemic stroke [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(2): 199-203.
[6]	Na WANG,Pei-lan LI,Lu-shan LIU,Feng-rong WANG. Prediction of Short- and Long-term Death in Patients with Acute Ischemic Stroke Using Various Scoring Systems [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(3): 256-260.
[7]	WANG Na-na, DU Xiao-zheng, HE Wen-jie, ZHANG Xin-yu, ZHENG Xin, LI Meng-xin. Roles of Notch Signaling Pathway in Acupuncture for Ischemic Stroke (review) [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(1): 67-70.
[8]	CHEN Xiao-ping,WANG Ming-yang,MA Deng-lei,GONG Shi-li,ZHANG Li,LI Ya-li,LI Lin,HU Chao-ying,ZHANG Lan. Effects of Analgecine on Apoptosis and Neuroinflammation in Cerebral Ischemia-reperfusion Injury Rats [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(9): 1038-1044.
[9]	LIU Jian-hua,WEI Qing-chuan,HU Xiu-ru,YE Sai-qing,YAN Zhi-yu,GAO Qiang. Relationship between Fractional Anisotropy of Diffusion Tensor Imaging and Motor Function after Ischemic Stroke [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(7): 749-752.
[10]	WEI Hai-ping,GUO Jia,WANG Huan,GE Zhao-ming. Effects of Vagus Nerve Stimulation on Adenosine Monophosphate Activated Protein Kinase-Silent Mating Type Information Regulation 2 Homolog 1 Pathway in Ischemia-reperfusion Rats [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(7): 775-779.
[11]	LIU Hui-zhen,GUO Shu-bin,SHANG Na,LI Fang,LIU Lu-shan,LI Pei-lan,CHEN Jing-mian,WANG Feng-rong,LI Jun-yu. Prediction of Serum 25-Hydroxyvitamin D for Outcome of Acute Ischemic Stroke in Emergency [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(7): 830-835.
[12]	GONG Shi-li,YANG Cui-cui,HU Chao-ying,WANG Ming-yang,ZHANG Lan. Promotion of Analgecine on Polarization of M1 Microglia to M2 and Inhibition on Secretion of Inflammatory Factors in Vitro [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(6): 662-667.
[13]	WANG Chuan-jie,WU Yi,TAO Feng,YANG Lei. Effects of Enriched Environment on Cognition and Expression of Bcl-2/Bax Protein in Hippocampus after Ischemic Stroke in Mice [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(5): 539-543.
[14]	DENG Du-ping,FAN Jin,XIE Xiao-long,LI Ling-xin. Advances in Drugs for Microglia Polarization after Ischemic Stroke (review) [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(5): 559-562.
[15]	FU Jia-wu,WU Hao,LI Jun-liang,YE Ye,CHEN Jing,ZHOU Hai-hong,LI You. Association between microRNA-137 Gene Polymorphisms and Ischemic Post-stroke Depression [J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(5): 588-591.

Effect of Enteral Nutrition on Intestinal Flora in Patients with Ischemic Stroke

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 0