脊髓损伤后疼痛治疗的研究进展

doi:10.3969/j.issn.1006-9771.2019.06.007

Abstract

Abstract: Pain post spinal cord injury (SCI) is treated clinically with drug and non-drug treatments, commonly including opioid analgesics, antiepileptics, antidepressants, acupuncture and moxibustion, stimulation therapy, surgical treatment, and so on. The effect of the drug treatment is obvious but following serious side effect; the non-drug treatment has small side effect and is safe and controllable, which has shown great development potential with the development of science and technology although the treatment effect is not certain.

Key words: spinal cord injury, pain, treatment, review

CLC Number:

R651.2

FENG Zhen-fen, ZHOU Bin-bin, WEI Wei-bing, QIN Jing-yu, LI Jian-nan. Advance in Pain Treatment post Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(6): 652-656.

References

1 SiddallP J, McClellandJ M, RutkowskiS B, et al. A longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injury [J]. Pain, 2003, 103(3): 249-257.
2 BryceT N. Opioids should not be prescribed for chronic pain after spinal cord injury [J]. Spinal Cord Ser Cases, 2018, 4: 66.
3 NorrbrinkC, LundebergT. Tramadol in neuropathic pain after spinal cord injury: a randomized, double-blind, placebo-controlled trial [J]. Clin J Pain, 2009, 5(3): 177-184.
4 AttalN, GuirimandF, BrasseurL, et al. Effects of IV morphine in central pain: a randomized placebo-controlled study [J]. Neurology, 2002, 58(4): 554-563.
5 SiddallP J, MolloyA R, WalkerS, et al. The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury [J]. Anesth Analg, 2000, 91(6): 1493-1498.
6 HookM A, WollerS A, BancroftE, et al. Neurobiological effects of morphine after spinal cord injury [J]. J Neurotrauma, 2017, 34(3): 632-644.
7 Barrera-ChaconJ M, Mendez-SuarezJ L, Jáuregui-AbrisquetaM L, et al. Oxycodone improves pain control and quality of life in anticonvulsant-pretreated spinal cord-injured patients with neuropathic pain [J]. Spinal Cord, 2011, 49(1): 36-42.
8 FinnerupN B, Biering-SØrensenF, JohannesenI L, et al. Intravenous lidocaine relieves spinal cord injury pain: a randomized controlled trial [J]. Anesthesiology, 2005, 102(5): 1023-1030.
9 Chiou-TanF Y, TuelS M, JohnsonJ C, et al. Effect of mexiletine on spinal cord injury dysesthetic pain [J]. Am J Phys Med Rehabil, 1996, 75(2): 84-87.
10 KvarnströmA, KarlstenR, QuidingH, et al. The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury [J]. Acta Anaesthesiol Scand, 2004, 48(4): 498-506.
11 AmrY M. Multi-day low dose ketamine infusion as adjuvant to oral gabapentin in spinal cord injury related chronic pain: a prospective, randomized, double blind trial [J]. Pain Physician, 2010, 13(3): 245-249.
12 KimK, MishinaM, KokuboR, et al. Ketamine for acute neuropathic pain in patients with spinal cord injury [J]. J Clin Neurosci, 2013, 20(6): 804-807.
13 SandfordP R, BenesP S. Use of capsaicin in the treatment of radicular pain in spinal cord injury [J]. J Spinal Cord Med, 2000, 23(4): 238-243.
14 MückeM, PhillipsT, RadbruchL, et al. Cannabis-based medicines for chronic neuropathic pain in adults [J]. Cochrane Database Syst Rev, 2018, 3: CD012182.
15 CardenasD D, NieshoffE C, SudaK, et al. A randomized trial of pregabalin in patients with neuropathic pain due to spinal cord injury [J]. Neurology, 2013, 80(6): 533-539.
16 YuX, LiuT, ZhaoD, et al. Efficacy and safety of pregabalin in neuropathic pain followed spinal cord injury: a review and meta-analysis of randomized controlled trials [J]. Clin J Pain, 2019, 35(3): 272-278.
17 MehtaS, McIntyreA, DijkersM, et al. Gabapentinoids are effective in decreasing neuropathic pain and other secondary outcomes after spinal cord injury: a meta-analysis [J]. Arch Phys Med Rehabil, 2014, 95(11): 2180-2186.
18 OttoM, BachF W, JensenT S, et al. Valproic acid has no effect on pain in polyneuropathy: a randomized, controlled trial [J]. Neurology, 2004, 62(2): 285-288.
19 FinnerupN B, GrydehøjJ, BingJ, et al. Levetiracetam in spinal cord injury pain: a randomized controlled trial [J]. Spinal Cord, 2009, 47(12): 861-867.
20 FinnerupN B, SindrupS H, BachF W, et al. Lamotrigine in spinal cord injury pain: a randomized controlled trial [J]. Pain, 2002, 96(3): 375-383.
21 AgarwalN, JoshiM. Effectiveness of amitriptyline and lamotrigine in traumatic spinal cord injury-induced neuropathic pain: a randomized longitudinal comparative study [J]. Spinal Cord, 2017, 55(2): 126-130.
22 SalinasF A, LugoL H, GarcíaH I. Efficacy of early treatment with carbamazepine in prevention of neuropathic pain in patients with spinal cord injury [J]. Am J Phys Med Rehabil, 2012, 91(12): 1020-1027.
23 AttalN. Pharmacological treatments of neuropathic pain: The latest recommendations [J]. Rev Neurol (Paris), 2019, 175(1-2): 46-50.
24 CardenasD D, WarmsC A, TurnerJ A, et al. Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial [J]. Pain, 2002, 96(3): 365-373.
25 RintalaD H, HolmesS A, CourtadeD, et al. Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury [J]. Arch Phys Med Rehabil, 2007, 88(12): 1547-1560.
26 MehtaS, GuyS, LamT, et al. Antidepressants are effective in decreasing neuropathic pain after SCI: a meta-analysis [J]. Top Spinal Cord Inj Rehabil, 2015, 21(2): 166-173.
27 LunnM P, HughesR A, WiffenP J. Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia [J]. Cochrane Database Syst Rev, 2014(1): CD007115.
28 VrankenJ H, HollmannM W, van der VegtM H, et al. Duloxetine in patients with central neuropathic pain caused by spinal cord injury or stroke: a randomized, double-blind, placebo-controlled trial [J]. Pain, 2011, 152(2): 267-273.
29 TeasellR W, MehtaS, AubutJ A, et al. A systematic review of pharmacologic treatments of pain after spinal cord injury [J]. Arch Phys Med Rehabil, 2010, 91(5): 816-831.
30 HanZ A, SongD H, OhH M, et al. Botulinum toxin type A for neuropathic pain in patients with spinal cord injury [J]. Ann Neurol, 2016, 79(4): 569-578.
31 LiG, LvC A, TianL, et al. A randomized controlled trial of Botulinum toxin A for treating neuropathic pain in patients with spinal cord injury [J]. Medicine (Baltimore), 2017, 96(20): e6919.
32 ChoiD C, LeeJ Y, LimE J, et al. Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats [J]. Exp Neurol, 2012, 236(2): 268-282.
33 LeeJ Y, ChoiD C, OhT H, et al. Analgesic effect of acupuncture is mediated via inhibition of JNK activation in astrocytes after spinal cord injury [J]. PLoS One, 2013, 8(9): e73948.
34 GwakY S, KimH Y, LeeB H, et al. Combined approaches for the relief of spinal cord injury-induced neuropathic pain [J]. Complement Ther Med, 2016, 25: 27-33.
35 EstoresI, ChenK, JacksonB, et al. Auricular acupuncture for spinal cord injury related neuropathic pain: a pilot controlled clinical trial [J]. J Spinal Cord Med, 2017, 40(4): 432-438.
36 GuyS D, MehtaS, CasalinoA, et al. The CanPain SCI Clinical Practice Guidelines for Rehabilitation Management of Neuropathic Pain after Spinal Cord: Recommendations for treatment [J]. Spinal Cord, 2016, 54(Suppl 1): S14-S23.
37 LovasJ, TranY, MiddletonJ, et al. Managing pain and fatigue in people with spinal cord injury: a randomized controlled trial feasibility study examining the efficacy of massage therapy [J]. Spinal Cord, 2017, 55(2): 162-166.
38 DetloffM R, SmithE J, Quiros MolinaD, et al. Acute exercise prevents the development of neuropathic pain and the sprouting of non-peptidergic (GDNF- and artemin-responsive) c-fibers after spinal cord injury [J]. Exp Neurol, 2014, 255: 38-48.
39 CratsenbergK A, DeitrickC E, HarringtonT K, et al. Effectiveness of exercise programs for management of shoulder pain in manual wheelchair users with spinal cord injury [J]. J Neurol Phys Ther, 2015, 39(4): 197-203.
40 HeutinkM, PostM W, LuthartP, et al. Long-term outcomes of a multidisciplinary cognitive behavioural programme for coping with chronic neuropathic spinal cord injury pain [J]. J Rehabil Med, 2014, 46(6): 540-545.
41 JensenM P, BarberJ, RomanoJ M, et al. Effects of self-hypnosis training and EMG biofeedback relaxation training on chronic pain in persons with spinal-cord injury [J]. Int J Clin Exp Hypn, 2009, 57(3): 239-268.
42 RichardsonE J, McKinleyE C, RahmanA, et al. Effects of virtual walking on spinal cord injury-related neuropathic pain: A randomized, controlled trial [J]. Rehabil Psychol, 2019, 64(1): 13-24.
43 ChiB, ChauB, YeoE, et al. Virtual reality for spinal cord injury-associated neuropathic pain: systematic review [J]. Ann Phys Rehabil Med, 2019, 62(1): 49-57.
44 CelikE C, ErhanB, GunduzB, et al. The effect of low-frequency TENS in the treatment of neuropathic pain in patients with spinal cord injury [J]. Spinal Cord, 2013, 51(4): 334-337.
45 BiX, LvH, ChenB L, et al. Effects of transcutaneous electrical nerve stimulation on pain in patients with spinal cord injury: a randomized controlled trial [J]. J Phys Ther Sci, 2015, 27(1): 23-25.
46 ZebA, ArshA, BahadurS, et al. Effectiveness of transcutaneous electrical nerve stimulation in management of neuropathic pain in patients with post traumatic incomplete spinal cord injuries [J]. Pak J Med Sci, 2018, 34(5): 1177-1180.
47 NgernyamN, JensenM P, ArayawichanonP, et al. The effects of transcranial direct current stimulation in patients with neuropathic pain from spinal cord injury [J]. Clin Neurophysiol, 2015, 126(2): 382-390.
48 WrigleyP J, GustinS M, McIndoeL N, et al. Longstanding neuropathic pain after spinal cord injury is refractory to transcranial direct current stimulation: a randomized controlled trial [J]. Pain, 2013, 154(10): 2178-2184.
49 MehtaS, McIntyreA, GuyS, et al. Effectiveness of transcranial direct current stimulation for the management of neuropathic pain after spinal cord injury: a meta-analysis [J]. Spinal Cord, 2015, 53(11): 780-785.
50 GaoF, ChuH, LiJ, et al. Repetitive transcranial magnetic stimulation for pain after spinal cord injury: a systematic review and meta-analysis [J]. J Neurosurg Sci, 2017, 61(5): 514-522.
51 LiS, DavisM, FronteraJ E, et al. A novel nonpharmacological intervention－breathing-controlled electrical stimulation for neuropathic pain management after spinal cord injury: a preliminary study [J]. J Pain Res, 2016, 9: 933-940.
52 LiS, StampasA, FronteraJ, et al. Combined transcranial direct current stimulation and breathing-controlled electrical stimulation for management of neuropathic pain after spinal cord injury [J]. J Rehabil Med, 2018, 50(9): 814-820.
53 MehtaS, OrenczukK, McIntyreA, et al. Neuropathic pain post spinal cord injury part 2: systematic review of dorsal root entry zone procedure [J]. Top Spinal Cord Inj Rehabil, 2013, 19(1): 78-86.
54 ChivukulaS, TempelZ J, ChenC J, et al. Spinal and nucleus caudalis dorsal root entry zone lesioning for chronic pain: efficacy and outcomes [J]. World Neurosurg, 2015, 84(2): 494-504.

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Advance in Pain Treatment post Spinal Cord Injury (review)

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