经颅磁刺激技术在脊髓损伤后痉挛中的应用机制进展

doi:10.3969/j.issn.1006-9771.2019.06.005

Abstract

Abstract: Spasticity is one of the common symptoms in patients with spinal cord injury, the mechanism can be summarized that the disappearance of the inhibition signals of descending pass of the spinal cord lead to the change of the balance between the circuit of the feedback and feedforward formed by the intra spindle muscle and extra spindle muscle, and the spasticity appear. Transcranial magnetic stimulation (TMS) can release the spasticity through increasing the excitability of the inhibitory interneurons to decrease the excitability of the spinal level. This article discussed about the mechanism of the spasticity after spinal cord injury first and then summarized the application and the therapeutic theory of the TMS on it.

Key words: spinal cord injury, spasticity, transcranial magnetic stimulation, review

CLC Number:

R651.2

Chin-hsuan CHIA, WU Yi. Advance in Transcranial Magnetic Stimulation for Spasticity post Spinal Cord Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(6): 644-647.

References

1 SminkeyL. Spinal cord injury [EB/OL]. (2013-12-02) [2016/10/13]. www.who.int/mediacentre/news/releases/2013/spinal-cord-injury-20131202/en/.
2 TazoeT, PerezM A. Effects of repetitive transcranial magnetic stimulation on recovery of function after spinal cord injury [J]. Arch Phys Med Rehabil, 2015, 96(4): S145-S155.
3 MukherjeeA, ChakravartyA. Spasticity Mechanisms: for the Clinician [J]. Front Neurol, 2010, 1(49): 1-10.
4 SköldC, LeviR, SeigerA. Spasticity after traumatic spinal cord injury: nature, severity, and location [J]. Arch Phys Med Rehabil, 1999, 80(12): 1548-1557.
5 MaynardF M, KarunasR S. Epidemiology of spasticity following traumatic spinal cord injury [J]. Arch Phys Med Rehabil, 1990, 71(8): 559-566.
6 DitunnoJ F, LittleJ W, TesslerA, et al. Spinal shock revisited: a four-phase model [J]. Spinal Cord, 2004, 42(7): 383-395.
7 AshbyP, VerrierM, LightfootE. Segmental reflex pathways in spinal shock and spinal spasticity in man [J]. J Neurol Neurosurg Psychiatry, 1974, 37(12): 1352-1360.
8 HiersemenzelL P, CurtA, DietzV. From spinal shock to spasticity neuronal adaptations to a spinal cord injury [J]. Neurology, 2000, 54(8): 1574-1582.
9 LiY, BennettD J. Persistent sodium and calcium currents cause plateau potentials in motoneurons of chronic spinal rats [J]. J Neurophysiol, 2003, 90(2): 857-869.
10 HeckmanC J, GorassiniM A, BennettD J. Persistent inward currents in motoneuron dendrites: implications for motor output [J]. Mucscle Nerve, 2005, 31(2): 135-156.
11 LiY, GorassiniM A, BennettD J. Role of persistent sodium and calcium currents in motoneuron firing and spasticity in chronic spinal rats [J]. J Neurophysiol, 2004, 91(2): 767-783.
12 MoritzA T, NewkirkG, PowersR K, et al. Facilitation of somatic calcium channels can evoke prolonged tail currents in rat hypoglossal motoneurons [J]. J Neurophysiol, 2007, 98(2): 1042-1047.
13 RudominP, SchmidtR F. Presynaptic inhibition in the vertebrate spinal cord revisited [J]. Exp Brain Res, 1999, 129(1): 1-37.
14 MailisA, AshbyP. Alterations in group Ia projections to motoneurons following spinal lesions in humans [J]. J Neurophysiol, 1990, 64(2): 637-647.
15 ShahaniB T, YoungR R. The flexor reflex in spasticity [D]. Chicago: Yearbook Medical Publishers, 1980.
16 RankM M, MurrayK C, StephensM J, et al. Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury [J]. J Neurophysiol, 2011, 105(1): 410-422.
17 Biering-SorensenB, KristensenI B, KjaerM, et al. Muscle after spinal cord injury [J]. Muscle Nerve, 2009, 40(4): 499-519.
18 ScelsiR, MarchettiC, PoggiP, et al. Muscle fiber type morphology and distribution in paraplegic patients with traumatic cord lesion. Histochemical and ultrastructural aspects of rectus femoris muscle [J]. Acta Neuropathol, 1982, 57(4): 243-248.
19 NielsenJ B, CroneC, HultbornH. The spinal pathophysiology of spasticity? From a basic science point of view [J]. Acta Physiol (Oxf), 2007, 189(2): 171-180.
20 LittleJ W, MicklessenP, UmlaufR, et al. Lower extremity manifestations of spasticity in chronic spinal cord injury [J]. Am J Phys Med Rehabil, 1989, 68(1): 32-36.
21 Beres-JonesJ A, JohnsonT D, HarkemaS J. Clonus after human spinal cord injury cannot be attributed solely to recurrent muscle-tendon stretch [J]. Exp Brain Res, 2003, 149(2): 222-236.
22 SchmitB D, BenzE N, RymerW Z. Reflex mechanisms for motor impairment in spinal cord injury [J]. Adv Exp Med Biol, 2002, 508(NA): 315-323.
23 D'AmicoJ M, CondliffeE G, MartinsK J B, et al. Recovery of neuronal and network excitability after spinal cord injury and implications for spasticity [J]. Front Integr Neurosci, 2014, 8(36): 1-24.
24 ElbasiounyS M, MorozD, BakrM M, et al. Management of spasticity after spinal cord injury: current techniques and future directions [J]. Neurorehabil Neural Repair, 2010, 24(1): 23-33.
25 BarkerA T, JalinousR, FreestonI L. Non-invasive magnetic stimulation of human motor cortex [J]. Lancet, 1985, 325(8437): 1106-1107.
26 ChervyakovA V, ChernyavskyA Y, SinitsynD O, et al. Possible mechanisms underlying the therapeutic effects of transcranial magnetic stimulation [J]. Front Hum Neurosci, 2015, 9(303): 1-14.
27 KobayashiM, PascualleoneA. Transcranial magnetic stimulation in neurology [J]. Lancet Neurol, 2003, 2(3): 145-156.
28 BenitoJ, KumruH, MurlloN. Motor and gait improvement in patients with incomplete spinal cord injury induced by highfrequency repetitive transcranial magnetic stimulation [J]. Top Spinal Cord Inj Rehabil, 2012, 18(2): 106-112.
29 KumruH, MurilloN, Vidal SamsoJ, et al. Reduction of spasticity with repetitive transcranial magnetic stimulation in patients with spinal cord injury [J]. Neurorehabil Neural Repair, 2010, 24(5): 435-441.
30 MoriF, CodecàC, KusayanagiH, et al. Effects of intermittent theta burst stimulation on spasticity in patients with multiple sclerosis [J]. Eur J Neurol, 2010, 17(2): 295-300.
31 HuangY, EdwardsM J, RounisE, et al. Theta burst stimulation of the human motor cortex [J]. Neuron, 2005, 45(2): 201-206.
32 Di LazzaroV, PilatoF, DileoneM, et al. The physiological basis of the effects of intermittent theta burst stimulation of the human motor cortex [J]. J Physiol, 2008, 586(16): 3871-3879.
33 NardoneR, LlerY H, ThomschewskiA, et al. rTMS modulates reciprocal inhibition in patients with traumatic spinal cord injury [J]. Spinal Cord, 2014, 52(11): 831-835.
34 KorzhovaJ, SinitsynD, ChervyakovA, et al. Transcranial and spinal cord magnetic stimulation in treatment of spasticity. A literature review and meta-analysis [J]. Eur J Phys Rehabil Med, 2016, 54(1): 1-29.
35 NardoneR, HöllerY, BrigoF, et al. Descending motor pathways and cortical physiology after spinal cord injury assessed by transcranial magnetic stimulation: a systematic review [J]. Brain Res, 2015, 1619: 139-154.
36 KimD H, ShinJ C, JungS, et al. Effects of intermittent theta burst stimulation on spasticity after stroke [J]. Neuroreport, 2015, 26(10): 561-566.

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Advance in Transcranial Magnetic Stimulation for Spasticity post Spinal Cord Injury (review)

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