Abstract: Objective To observe the effect of eradication of helicobacter pylori (Hp) combined with comprehensive rehabilitation treatment on patients with non-alcoholic fatty liver disease (NAFLD). Methods From December, 2015 to April, 2016, 219 patients diagnosed as NAFLD with Hp infection were enrolled, in which 119 patients (observation group) were treated with anti Hp quadruple therapy. They were tested with ¹³C urea breath test one month after drug withdrawal. The other 100 patients were as control group. The severity of NAFLD was observed with abdominal ultrasound after six months. Results After treatment, Hp was eradicated in 107 cases (90.68%) in the observation group, one dropped out for pulmonary infection. After six months, the severity of NAFLD improved better in the patients eradicated Hp in the observation group than in the control group (χ²=8.397, P<0.05). Conclusion Eradication of Hp combined with comprehensive rehabilitation treatment can improve the severity of NAFLD.

Key words: non-alcoholic fatty liver disease, helicobacter pylori, exercise, quadruple therapy