Abstract: Objective To investigate the relationship between fatigue and motor dysfunction in patients with Parkinson's disease(PD).Methods 139 PD patients were assessed with Fatigue Severe Scale(FSS) and divived into the fatigue group and non-fatigue group. The motor function, depression and cognitive function were assessed with Unified Pakinson's Disease Rating Scale(UPDRS), Hamilton Depression Scale and mini-mental state examination(MMSE) respectively. The Spearman's rank correlation coefficient was used to evaluate the correlation between fatigue and motor dysfunction.Results 70 patients had fatigue. The UPDRS motor subscale score of the fatigue group was significantly higher than the non-fatigue group (P<0.05). The UPDRS score of rigidity items and bradykinesia items of the fatigue group were significantly higher than those of the non-fatigue group(P<0.05), with no significant difference in UPSRS score of tremor items between the two groups (P>0.05). There was significant correlation between FSS score and UPDRS motor score (P<0.05). Conclusion Fatigue is one of the common symptoms of PD and correlates with motor dysfunction.

Key words: Parkinson's disease, fatigue, motor dysfunction