多靶区经颅直流电刺激对健康成年人工作记忆-姿势控制双任务表现的影响

doi:10.3969/j.issn.1006-9771.2024.01.003

《中国康复理论与实践》 ›› 2024, Vol. 30 ›› Issue (1): 21-28.doi: 10.3969/j.issn.1006-9771.2024.01.003

多靶区经颅直流电刺激对健康成年人工作记忆-姿势控制双任务表现的影响

周治宁¹, 周容¹, 肖燕文¹^,², 王博文¹, 吕娇娇¹(), 刘宇¹

1.上海体育大学运动健身科技省部共建教育部重点实验室，上海市 200438
2.中山大学孙逸仙纪念医院深汕中心医院，广东汕尾市 516600

收稿日期:2023-10-13 修回日期:2023-12-08 出版日期:2024-01-25 发布日期:2024-02-04
通讯作者: 吕娇娇，女，汉族，博士，副教授，主要研究方向：双任务姿势控制的神经调控。E-mail：ljj27@163.com
作者简介:周治宁(1997-)，男，汉族，山东临邑县人，博士研究生，主要研究方向：双任务姿势控制的电刺激调控。
基金资助:
1.国家自然科学基金项目(11932013);国家自然科学基金项目(12302418);2.上海市体育科技项目(24J013)

Effect of multi-target transcranial direct current stimulation on performance of working memory-postural control dual-task in healthy adults

ZHOU Zhining¹, ZHOU Rong¹, XIAO Yanwen¹^,², WANG Bowen¹, LÜ Jiaojiao¹(), LIU Yu¹

1. Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China
2. Shenshan Medical Center, Memorial Hospital of Sun Yat-sen University, Shanwei, Guangdong 516600, China

Received:2023-10-13 Revised:2023-12-08 Published:2024-01-25 Online:2024-02-04
Contact: LÜ Jiaojiao, E-mail: ljj27@163.com
Supported by:
Natural Science Foundation of China(11932013);Natural Science Foundation of China(12302418);Sports Science & Technology Project of Shanghai(24J013)

摘要/Abstract

摘要：

目的探究多靶区经颅直流电刺激(tDCS)和单靶区tDCS对健康成年人工作记忆-姿势控制双任务表现的影响，并比较两种刺激方案的调控效果。

方法 2020年11月至2021年2月，招募上海体育大学19例健康成年人，随机接受多靶区tDCS、单靶区tDCS和假刺激，任意两种刺激之间至少间隔1周。其中，多靶区tDCS的目标靶区为左侧背外侧前额叶(L-DLPFC)和双侧初级运动皮质(M1)；单靶区tDCS仅刺激L-DLPFC。在每种刺激前后，所有受试者进行单任务和双任务条件下的步行和站立平衡测试，双任务中的第二任务为N-back任务。刺激前后观察双任务姿势控制表现、双任务消耗(DTC)和工作记忆表现。

结果刺激后，3种刺激间双任务步行的步幅变异性(F = 3.792, P = 0.029)、步幅变异性_{_DTC}(F = 3.412, P = 0.040)以及双任务站立平衡的压心摆动速度(Vcop) (F = 3.815, P = 0.029)有显著性差异。与假刺激相比，多靶区tDCS后，步幅变异性(P = 0.047)和Vcop (P = 0.015)降低，步幅变异性_{_DTC}有降低趋势(P = 0.073)；单靶区tDCS后，步幅变异性(P = 0.011)、步幅变异性_{_DTC}(P = 0.014)和Vcop (P = 0.025)均降低。与单靶区tDCS相比，多靶区tDCS后，压心摆动面积的双任务消耗降低(P = 0.035)。3种刺激后受试者工作记忆表现改变无显著性差异(P > 0.05)。

结论多靶区tDCS和单靶区tDCS均可调控健康成年人的工作记忆-姿势控制双任务表现；且与单靶区tDCS相比，多靶区tDCS在调控站立平衡双任务姿势控制效果上具有一定优势。

关键词: 双任务, 姿势控制, 工作记忆, 背外侧前额叶, 初级运动皮质, 经颅直流电刺激

Abstract:

Objective To investigate the effect of multi-target transcranial direct current stimulation (tDCS) and single-target tDCS on the performance of working memory-postural control dual-task in healthy adults, and to compare the regulatory effect of the two stimulation protocols.

Methods From November, 2020 to February, 2021, 19 healthy adults in Shanghai University of Sport were recruited and randomly accepted multi-target tDCS, single-target tDCS and sham stimulation with at least one week interval between any two stimulation protocols. The target areas of multi-target tDCS included left dorsal lateral prefrontal cortex (L-DLPFC) and bilateral primary motor cortex (M1), and single-tDCS only applied to L-DLPFC. Before and after stimulation, participants completed walking and standing balance tests under single task and dual-task conditions with the second task being a N-back task. The dual-task postural control performance, dual-task cost (DTC) and working memory performance were observed before and after stimulation.

Results Significant differences were observed among three stimulation protocols in the changes of stride variability (F = 3.792, P= 0.029), DTC of stride variability (F = 3.412, P= 0.040) and velocity of center of pressure (Vcop) (F = 3.815, P= 0.029). The stride variability (P = 0.047) and Vcop (P = 0.015) were significantly lower and the decrease in DTC of stride variability tended to be significant (P = 0.073) following multi-target tDCS, as compared to sham stimulation. Single-target tDCS significantly decreased the changes of stride variability (P = 0.011), DTC of stride variability (P = 0.014) and Vcop (P = 0.025), as compared to sham stimulation. Compared with single target tDCS, multi-target tDCS reduced the changes of the dual-task cost of the area of center of pressure (P = 0.035). Moreover, no significant difference was observed among the three stimulation protocols in the changes of each measure in the working memory test (P> 0.05).

Conclusion Both multi-target tDCS and single-target tDCS can improve the performance of working memory-postural control dual-task in healthy adults, and compared with single-target tDCS, multi-target tDCS has some advantages in regulating postural control.

Key words: dual-task, postural control, working memory, dorsal lateral prefrontal cortex, primary motor cortex, transcranial direct current stimulation

中图分类号:

R741.05

周治宁, 周容, 肖燕文, 王博文, 吕娇娇, 刘宇. 多靶区经颅直流电刺激对健康成年人工作记忆-姿势控制双任务表现的影响[J]. 《中国康复理论与实践》, 2024, 30(1): 21-28.

ZHOU Zhining, ZHOU Rong, XIAO Yanwen, WANG Bowen, LÜ Jiaojiao, LIU Yu. Effect of multi-target transcranial direct current stimulation on performance of working memory-postural control dual-task in healthy adults[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2024, 30(1): 21-28.

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指标	多靶区tDCS	单靶区tDCS	假刺激	F值	P值
步幅/cm	-0.706±5.874	-0.435±5.010	-1.496±4.089	0.218	0.805
步速/(cm•s^-1)	-1.785±9.769	-2.058±7.951	-3.744±6.062	0.314	0.732
步幅变异性/%	-0.465±0.977^a	-0.748±1.563^c	0.498±1.685	3.792	0.029
步速变异性/%	-0.082±1.023	0.362±3.000	0.751±2.966	0.517	0.599
步幅_{_DTC}/%	0.498±3.767	-0.151±5.002	0.074±3.253	0.123	0.884
步速_{_DCT}/%	-0.412±6.813	-1.481±8.273	-0.435±6.564	0.133	0.876
步幅变异性_{_DTC}/%	-24.263±136.898^b	-54.952±140.630^d	55.199±116.017	3.412	0.040
步速变异性_{_DTC}/%	-8.418±88.656	11.476±139.416	16.113±120.925	0.228	0.797

指标	多靶区tDCS	单靶区tDCS	假刺激	F值	P值
Acop/cm²	-0.031±0.413	0.103±0.413	0.197±0.674	0.931	0.401
Vcop/(cm•s^-1)	-0.812±5.298^a	-0.395±5.241^b	4.235±7.178	3.815	0.029
Acop_{_DTC}/%	-0.076±0.230^c	0.101±0.165	-0.002±0.344	2.366	0.104
Vcop_{_DTC}/%	-0.348±1.081	0.226±0.703	0.273±1.497	1.757	0.183

指标	多靶区tDCS	单靶区tDCS	假刺激	F值	P值
准确率	0.021±0.091	0.003±0.047	0.004±0.046	0.020	0.980
反应时/ms	0.029±0.125	0.001±0.095	-0.057±0.136	1.115	0.335
IES/ms	-0.024±0.050	-0.015±0.038	-0.071±0.040	0.508	0.605

多靶区经颅直流电刺激对健康成年人工作记忆-姿势控制双任务表现的影响

Effect of multi-target transcranial direct current stimulation on performance of working memory-postural control dual-task in healthy adults

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