经颅微电流刺激对老年轻度认知功能障碍的效果

doi:10.3969/j.issn.1006-9771.2022.03.011

摘要/Abstract

摘要： 目的探讨经颅微电流刺激(CES)对老年轻度认知功能障碍患者认知功能的疗效。方法选择2018年至2019年在本院住院的老年轻度认知障碍患者40例,随机分为对照组(n = 20)和治疗组(n = 20)。两组均接受常规药物治疗(无促认知药物);治疗组增加CES治疗,共8周。治疗前,治疗后4周、8周,由两人采用改良Barthel指数(MBI)和蒙特利尔认知评估量表(MoCA)进行单盲评定。对照组于8周后予免费CES治疗。结果 MoCA评分时间主效应显著(F = 5.603, P = 0.007),组间主效应不显著(F = 2.160, P = 0.150),交互效应显著(F = 9.160, P < 0.001),治疗组高于对照组。MBI时间主效应(F = 0.322, P = 0.726)、组间主效应(F = 0.009, P = 0.925)和交互效应(F = 0.322, P = 0.726)均不显著。CES干预过程中未见不良反应。结论 CES对老年轻度认知功能障碍的干预可能有效。

关键词: 老年, 轻度认知障碍, 经颅微电流刺激

Abstract: Objective To explore the effect of cranial electrotherapy stimulation (CES) on cognitive function for old patients with mild cognitive impairment.Methods A total of 40 old inpatients with mild cognitive impairment in 2018 and 2019 were randomly divided into control group (n = 20) and treatment group (n = 20). Both groups accepted routine medication (without cognitive drugs), and the treatment group accepted CES in addition, for eight weeks. They were assessed with modified Barthel Index (MBI) and Montreal Cognitive Assessment (MoCA) by two researchers single-blind before treatment, and four and eight weeks after treatment. The control group accepted free CES after trial.Results For MoCA score, the main effect was significant in time (F = 5.603, P = 0.007), not significant in group (F = 2.160, P = 0.150), and the effect of interaction was significant (F = 9.160, P < 0.001), which was more in the treatment group than in the control group. For MBI score, the main effects were not significant both in time (F = 0.322, P = 0.726) and in group (F = 0.009, P = 0.925), nor the effect of interaction (F = 0.322, P = 0.726). No adverse reactions occurred during CES intervention.Conclusion CES may be effective on mild cognitive impairment in old patients.

Key words: aged, mild cognitive impairment, cranial electrotherapy stimulation

史昊楠,谢瑛,桂沛君,张勃,陈宸. 经颅微电流刺激对老年轻度认知功能障碍的效果[J]. 《中国康复理论与实践》, 2022, 28(3): 346-349.

SHI Haonan,XIE Ying,GUI Peijun,ZHANG Bo,CHEN Chen. Effect of cranial electrotherapy stimulation on mild cognitive impairment for older adults[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(3): 346-349.

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组别	n	性别(男/女)/n	年龄/岁
对照组	20	12/8	71.65±9.19
治疗组	20	13/7	72.75±8.16
χ²/F值		0.107	0.331
P值		0.744	0.685

组别	n	治疗前	治疗后4周	治疗后8周
对照组	20	90.50±19.73	90.50±19.73	90.00±18.92
治疗组	20	89.50±19.60	90.00±19.87	89.75±18.81

组别	n	治疗前	治疗后4周	治疗后8周
对照组	20	23.80±1.01^a	23.80±1.06^a	23.70±1.13
治疗组	20	23.90±1.17^a	24.15±1.35^a,b	24.80±1.28^b