《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (01): 36-37.

• 基础研究 • 上一篇    下一篇

硝苯地平对野百合碱所致大鼠肺动脉高压的影响

胥方元; 何成松; 干锦华; 杨大鉴   

  1. 四川泸州医学院附属医院康复医学科 四川泸州市 646000
  • 收稿日期:2003-09-08 出版日期:2004-01-25 发布日期:2004-01-25

Effect of nifedipine on monocrotaline-induced pulmonary hypertension in rats

XU Fang-yuan, HE Cheng-song, GAN Jin-hua, et al   

  1. Department of Rehabilitation Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan, China
  • Received:2003-09-08 Published:2004-01-25 Online:2004-01-25

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被引次数

8

摘要： 目的探讨硝苯地平(Nif)对野百合碱(MCT)诱发慢性炎性肺动脉高压的防治作用。方法33只雄性Wistar大鼠随机分为正常对照组、肺动脉高压模型组、Nif治疗组,每组11只。予MCT(50mg/kg)制做大鼠肺动脉高压模型后,分别给Nif组及模型组大鼠连续灌胃Nif(20mg/kg·d)和等量生理盐水21d。采用改良右心导管术测定肺血流动力学参数;处死大鼠后,称量肺湿重(WW)、右心室自由壁(RV)和左心室加室间隔(LV+S)重,计算右心肥厚指数(RV/LV+S)。结果Nif能明显降低肺动脉高压模型大鼠的平均肺动脉压及RV/LV+S(P<0.01),但对WW无明显影响(P>0.05)。结论长期使用Nif能有效防治MCT所致肺动脉高压,改善心功能。

关键词: 硝苯地平, 野百合碱, 肺动脉高压, 大鼠

Abstract: ObjectiveTo investigate the effect of nifedipine(Nif) on experimental pulmonary hypertension(PH).Methods33 adult male Wistar rats were randomly divided into normal control group,model group and Nif treatment group(n=11 for each group). Rats were given a single dose of subcutaneous monocrotaline(MCT,50 mg/kg) to induce the model of pulmonary hypertension, then treated with gastric infusion of normal saline or Nif respectively for 21 days. The parameters of pulmonary hemodynamics were monitored by Gould3400 polygraph system through the cannulation of polyvinyl tube. Right ventricle and left ventricle added with interventricular septum weight ratio, and the lung wet weight were measured.ResultsNif significantly inhibited the progression of pulmonary artery pressure(P<0.01), decreased the right heart index(P<0.01), but did not significantly reduce the lung wet weight(P>0.05).ConclusionChronic treatment with Nif may effectively reduce the development of PH induced by MCT and improve the heart function.

Key words: nifedipine, monocrotaline, pulmonary hypertension, rat