下肢截肢患者的脑功能连接

doi:10.3969/j.issn.1006-9771.2022.01.013

《中国康复理论与实践》 ›› 2022, Vol. 28 ›› Issue (1): 90-94.doi: 10.3969/j.issn.1006-9771.2022.01.013

下肢截肢患者的脑功能连接

刘绍文^1,²,魏聪惠^1,²,单新颖²(),张焱¹()

1.南昌大学第二附属医院,江西南昌市 330006
2.国家康复辅具研究中心老年功能障碍工程康复北京市重点实验室,北京市 100176

收稿日期:2021-09-03 修回日期:2021-11-09 出版日期:2022-01-25 发布日期:2022-02-11
通讯作者: 单新颖,张焱 E-mail:shxy010411@163.com;doctorzhangyan@163.com
作者简介:刘绍文(1997-),男,汉族,江西兴国县人,硕士研究生,主要研究方向：神经康复。
基金资助:
国家重点研发项目(2020YFC2005801)

Brain functional connectivity in lower limb amputees

LIU Shaowen^1,²,WEI Conghui^1,²,SHAN Xinying²(),ZHANG Yan¹()

1. The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
2. Beijing Key Laboratory of Rehabilitation Technical Aids for Old-age Disability, National Research Center for Rehabilitation Technical Aids, Beijing 100176, China

Received:2021-09-03 Revised:2021-11-09 Published:2022-01-25 Online:2022-02-11
Contact: SHAN Xinying,ZHANG Yan E-mail:shxy010411@163.com;doctorzhangyan@163.com
Supported by:
National Key R & D Program of China(2020YFC2005801)

摘要/Abstract

摘要：

目的探究静息状态下,下肢截肢患者脑电信号在多频段上脑功能连接的变化。方法 2020年11月至2021年6月,采集22例健康成年人(对照组)和18例下肢截肢患者(患者组)静息态脑电图,以相位锁值构建功能连接矩阵,比较两组间差异。结果患者组α频段(t = 3.433, P = 0.001)和β频段(t = 3.806, P = 0.001)功能连接明显减弱,δ频段(t = 1.429, P = 0.161)和θ频段(t = 1.211, P = 0.233)功能连接与对照组无显著性差异。结论下肢截肢患者脑电α、β频段功能连接减弱,导致多个脑区功能重塑,包括相关肢体投射脑区、额叶、颞叶、枕叶等。

关键词: 下肢, 截肢, 静息态脑电, 功能连接, 相位锁值

Abstract:

Objective To investigate the changes of functional brain connectivity over multiple frequency bands in resting-state electroencephalography (EEG) for lower limb amputation patients. Methods Resting-state EEG was collected from 18 lower limb amputees and 22 healthy controls from November, 2020 to June, 2021. Functional connectivity matrix was constructed with phase-locked values (PLV), and compared between groups. Results The functional connectivity was weaker in the amputees than in the controls on α band (t = 3.433, P = 0.001) and β band (t = 3.806, P = 0.001), and there was no significant difference on δ band (t = 1.429, P = 0.161) and θ band (t = 1.211, P = 0.233). Conclusion EEG functional connectivity weakens in lower limb amputees in on the α and β band, which results in neuroplasticity of multiple brain regions, not only for limb-respond cortex, but also for frontal, temporal and occipital cortices.

Key words: lower limb, amputation, resting-state electroencephalography, functional connectivity, phase-locked values

中图分类号:

R687.5

刘绍文,魏聪惠,单新颖,张焱. 下肢截肢患者的脑功能连接[J]. 《中国康复理论与实践》, 2022, 28(1): 90-94.

LIU Shaowen,WEI Conghui,SHAN Xinying,ZHANG Yan. Brain functional connectivity in lower limb amputees[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(1): 90-94.

图/表 5

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下肢截肢患者的脑功能连接

Brain functional connectivity in lower limb amputees

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患者	性别	年龄/岁	截肢部位	病程/月	病因
1	女	57	小腿	8	交通事故
2	男	46	大腿	4	交通事故
3	男	41	小腿	7	交通事故
4	男	49	小腿	24	交通事故
5	男	49	大腿	14	交通事故
6	男	53	大腿	5	烧伤
7	男	33	大腿	6	交通事故
8	男	52	小腿	2	感染
9	女	66	大腿	8	交通事故
10	男	35	小腿	2	感染
11	男	46	小腿	19	交通事故
12	男	32	小腿	2	交通事故
13	男	34	小腿	19	电击伤
14	男	57	小腿	8	感染
15	男	62	大腿	13	交通事故
16	男	45	大腿	17	交通事故
17	男	44	大腿	20	肿瘤
18	男	50	小腿	5	交通事故

组别	n	δ	θ	α	β
对照组	22	0.70±0.02	0.56±0.02	0.51±0.03	0.46±0.03
患者组	18	0.70±0.02	0.55±0.02	0.47±0.03	0.42±0.04
t值		1.429	1.211	3.433	3.806
P值		0.161	0.233	0.001	0.001

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