《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (01): 34-35.

• 基础研究 • 上一篇    下一篇

欣舒注射液对兔血管内膜剥脱术后血小板活化及纤溶活性的影响

王承龙1; 杨积武1; 林钟香2   

  1. 1.辽宁中医学院附属医院 辽宁沈阳市 110032;2.上海中医药大学附属龙华医院 上海市 200032
  • 收稿日期:2003-11-17 出版日期:2004-01-25 发布日期:2004-01-25

Effects of XinShu Parenteral Solution on the function of platelet,the changes of fibrinolysis system after intima denudation of rabbits

WANG Cheng-long, YANG Ji-wu, LIN Zhong-xiang   

  1. Longhua Hospital, Shanghai University of TCM,200032 Shanghai,China
  • Received:2003-11-17 Published:2004-01-25 Online:2004-01-25

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摘要： 目的观察欣舒注射液(XSPS)对兔血管内膜剥脱术后血浆血小板α颗粒膜蛋白(GMP-140)及组织型纤溶酶原激活剂(t-PA)、Ⅰ型纤溶酶原激活物抑制因子(PAI-1)含量变化的影响。方法选取日本雄性大耳白兔20只,随机分为对照组和中药组,用球囊导管剥脱其腹主动脉内皮。分别于术前及术后3天、7天耳缘静脉采血测定血浆GMP-140,t-PA、PAI-1的含量。结果XSPS可显著降低血浆GMP-140水平,使t-PA升高、PAI-1下降,与对照组相比有显著性差异(P<0.05)。结论XSPS可明显抑制兔动脉损伤后血小板的活化,促进纤溶活性,从而抑制动脉成形术后血栓的形成,可能达到防治再狭窄的作用。

关键词: 欣舒注射液, 血管内膜剥脱术, 血小板α颗粒膜蛋白(GMP-140), 组织型纤溶酶原激活剂(t-PA), Ⅰ型纤溶酶原激活物抑制因子(PAI-1)

Abstract: ObjectiveTo observe the effects of XinShu parenteral solution (XSPS) on the activation of platelet, the activity of fibrinolysis system after intima denudation of rabbits.Methods20 male Japanese white rabbits (2.5±0.5)kg were randomly divided into the control group and XSPS group .The celiac arterial endothelium of all rabbits were denuded with balloon. Before the operation and 3d, 7d, after balloon denudation, vein blood samples were obtained from each group rabbits for measurement of α granule membrane protein of platelets(GMP-140), tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor-type Ⅰ(PAI-1).ResultsPlasma GMP-140 and PAI-1 activity obviously elevated after balloon injury, and there was a little elevation in plasma t-PA activity in control group. Activity of plasma GMP-140 in XSPS group remained bottom level after balloon injury, and there was a significant increase in plasma t-PA activity and a marked reduce in PAI-1 activity in XSPS group. There was a notable difference between group B and group C (P<0.05). ConclusionXSPS obviously inhibits platelet activation, and improves fibrinolysis activity after balloon injury.

Key words: XinShu parenteral solution(XSPS), intima denudation, α granule membrane protein of platelets(GMP-140), tissue-type plasminogen activator(t-PA), plasminogen activator inhibitor-type Ⅰ(PAI-1)