Kelch样环氧氯丙烷相关蛋白-1-核因子E2相关因子2/抗氧化反应元件抗氧化应激通路在多发性硬化中作用的研究进展

doi:10.3969/j.issn.1006-9771.2020.03.013

《中国康复理论与实践》 ›› 2020, Vol. 26 ›› Issue (3): 330-333.doi: 10.3969/j.issn.1006-9771.2020.03.013

Kelch样环氧氯丙烷相关蛋白-1-核因子E2相关因子2/抗氧化反应元件抗氧化应激通路在多发性硬化中作用的研究进展

苏玲玲,郑碧娥,何进娣,范建中,尹瑞雪()

南方医科大学南方医院康复医学科,广东广州市 510515

收稿日期:2018-12-20 修回日期:2019-01-29 出版日期:2020-03-25 发布日期:2020-04-01
通讯作者: 尹瑞雪 E-mail:yinruixueshen@126.com
作者简介:苏玲玲(1993-),女,汉族,福建泉州市人,硕士研究生,主要研究方向：神经康复。|尹瑞雪(1968-),女,汉族,河南内黄县人,博士,副主任医师,硕士研究生导师,主要研究方向：神经康复。
基金资助:
广东省自然科学基金项目(2016A030313523)

Role of Kelch-like ECH-associated Protein-1-Nuclear Factor Erythroid 2-related Factor-2/Antioxidant Responsive Element Signal Pathway for Multiple Sclerosis (review)

SU Ling-ling,ZHENG Bi-e,HE Jin-di,FAN Jian-zhong,YIN Rui-xue()

Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China

Received:2018-12-20 Revised:2019-01-29 Published:2020-03-25 Online:2020-04-01
Contact: YIN Rui-xue E-mail:yinruixueshen@126.com
Supported by:
Guangdong Natural Science Foundation(2016A030313523)

摘要/Abstract

摘要：

多发性硬化(MS)是一种慢性炎症性疾病,主要是由T淋巴细胞引起,可使中枢神经系统产生氧化应激反应,导致脱髓鞘等病理改变。Kelch样环氧氯丙烷相关蛋白-1 (Keap1)-核因子E2相关因子2 (Nrf2)/抗氧化反应元件(ARE)抗氧化应激通路是体内最重要的内源性抗氧化应激通路,激活该通路可启动下游解毒酶、抗氧化蛋白,参与清除氧自由基,维持细胞内氧化还原系统平衡,从而对神经退行性疾病起保护作用。通过药物或各种康复治疗手段激活该Keap1-Nrf2/ARE通路,减轻MS疾病进展的作用及未来MS治疗靶点是目前研究热点。

关键词: 多发性硬化, 氧化应激, Kelch样环氧氯丙烷相关蛋白-1, 核因子E2相关因子2, 抗氧化反应元件, 信号通路, 综述

Abstract:

Multiple sclerosis (MS) is a chronic inflammatory disease, mainly due to the activation of the T cells, which makes oxidative stress reaction in brain and leads to demyelination finally. Kelch-like ECH-associated protein-1 (Keap1)-nuclear factor erythroid 2-related factor-2 (Nrf2)/antioxidant responsive element (ARE) signal pathway is one of the most important endogenous antioxidant pathways, which promotes the expression of detoxification enzymes and antioxidant protein to eliminate oxygen free radicals and balance intracellular redox system. Activation of the Keap1-Nrf2/ARE may delay the progression of MS by drugs or rehabilitation.

Key words: multiple sclerosis, oxidative stress, Kelch-like ECH-associated protein-1, nuclear factor E2-related factor-2, antioxidant responsive element, signal pathway, review

中图分类号:

R744.5

苏玲玲,郑碧娥,何进娣,范建中,尹瑞雪. Kelch样环氧氯丙烷相关蛋白-1-核因子E2相关因子2/抗氧化反应元件抗氧化应激通路在多发性硬化中作用的研究进展[J]. 《中国康复理论与实践》, 2020, 26(3): 330-333.

SU Ling-ling,ZHENG Bi-e,HE Jin-di,FAN Jian-zhong,YIN Rui-xue. Role of Kelch-like ECH-associated Protein-1-Nuclear Factor Erythroid 2-related Factor-2/Antioxidant Responsive Element Signal Pathway for Multiple Sclerosis (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(3): 330-333.

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Kelch样环氧氯丙烷相关蛋白-1-核因子E2相关因子2/抗氧化反应元件抗氧化应激通路在多发性硬化中作用的研究进展

Role of Kelch-like ECH-associated Protein-1-Nuclear Factor Erythroid 2-related Factor-2/Antioxidant Responsive Element Signal Pathway for Multiple Sclerosis (review)

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