神经颗粒素对中枢神经系统疾病认知功能障碍作用的研究进展

doi:10.3969/j.issn.1006-9771.2020.03.012

《中国康复理论与实践》 ›› 2020, Vol. 26 ›› Issue (3): 325-329.doi: 10.3969/j.issn.1006-9771.2020.03.012

神经颗粒素对中枢神经系统疾病认知功能障碍作用的研究进展

张嘉泳^1,²,柳维林^1,²,陈立典¹,陶静¹()

1.福建中医药大学康复医学院,福建福州市 350122
2.福建省康复技术协同创新中心,福建福州市 350122

收稿日期:2019-07-11 修回日期:2019-09-23 出版日期:2020-03-25 发布日期:2020-04-01
通讯作者: 陶静 E-mail:taojing01@fjtcm.edu.cn
作者简介:张嘉泳(1994-),女,汉族,广东广州市人,硕士研究生,主要研究方向：神经康复与认知科学研究。|陶静,女,汉族,博士,教授,博士研究生导师,主要研究方向：神经康复与认知科学研究。
基金资助:
国家自然科学基金项目(81774424)

Advance in Neurogranin for Cognitive Impairment Second to Central Nervous System Diseases (review)

ZHANG Jia-yong^1,²,LIU Wei-lin^1,²,CHEN Li-dian¹,TAO Jing¹()

1. College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China
2. Fujian Collaborative Innovation Center for Rehabilitation Technology, Fuzhou, Fujian 350122, China

Received:2019-07-11 Revised:2019-09-23 Published:2020-03-25 Online:2020-04-01
Contact: TAO Jing E-mail:taojing01@fjtcm.edu.cn
Supported by:
National Natural Science Foundation of China(81774424)

摘要/Abstract

摘要：

神经颗粒素(Ng)是一种神经元特异性突触后蛋白,大量存在于大脑皮质和海马等部位,主要通过磷酸化反应和氧化还原作用改变与钙调蛋白的亲和力,并通过谷氨酸受体依赖方式参与钙信号传导途径,实现神经元间信息传导调控和突触可塑性调节。Ng在相关脑区参与记忆的形成和编码,在学习记忆和认知功能中发挥重要作用。Ng与阿尔茨海默病的认知功能下降有关,并可作为诊断阿尔茨海默病的突触生物标志物;脑卒中后认知功能障碍与大脑Ng表达减少有关;Ng还是精神分裂症易感性相关的基因变异之一。

关键词: 神经颗粒素, 突触可塑性, 认知功能障碍, 综述

Abstract:

Neurogranin (Ng), as a neuron-specific postsynaptic protein, is abundant in the cerebral cortex and hippocampus. Ng may alter the affinity with calmodulin through phosphorylation and redox, and participate in the calcium signal pathway through glutamate receptor, to regulate the information transfer and synaptic plasticity. Ng involves in the formation and encoding of memories in related brain regions and plays an important role in learning, memory and cognitive function. Ng is associated with cognitive decline in Alzheimer's disease and can be used as a synaptic biomarker for diagnosis. Cognitive dysfunction after stroke is associated with decrease of Ng expression in the brain. Ng is one of the sites of genetic variants associated with susceptibility to schizophrenia.

Key words: neurogranin, synaptic plasticity, cognitive impairment, review

中图分类号:

R741

张嘉泳,柳维林,陈立典,陶静. 神经颗粒素对中枢神经系统疾病认知功能障碍作用的研究进展[J]. 《中国康复理论与实践》, 2020, 26(3): 325-329.

ZHANG Jia-yong,LIU Wei-lin,CHEN Li-dian,TAO Jing. Advance in Neurogranin for Cognitive Impairment Second to Central Nervous System Diseases (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(3): 325-329.

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神经颗粒素对中枢神经系统疾病认知功能障碍作用的研究进展

Advance in Neurogranin for Cognitive Impairment Second to Central Nervous System Diseases (review)

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