肠道菌群与孤独症谱系障碍关系的研究进展

doi:10.3969/j.issn.1006-9771.2019.03.013

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (3): 319-323.doi: 10.3969/j.issn.1006-9771.2019.03.013

肠道菌群与孤独症谱系障碍关系的研究进展

张春艳^1,2, 朱路文^1,2, 唐强^1,2

1.黑龙江中医药大学第二临床医学院，黑龙江哈尔滨市 150040
2.黑龙江中医药大学附属第二医院，黑龙江哈尔滨市 150001

收稿日期:2019-01-15 修回日期:2019-02-26 出版日期:2019-03-25 发布日期:2019-04-02
通讯作者: 唐强,E-mail: tangqiang1963@163.com
作者简介:张春艳(1980-)，女，汉族，黑龙江哈尔滨市人，博士研究生，主治医师，主要研究方向：儿童神经系统疾病中医康复基础及临床研究。通讯作者：唐强(1963-)，男，教授，博士生导师，主要研究方向：神经系统疾病中医康复及临床研究。
基金资助:
1.黑龙江中医药大学科研基金项目(No. 201517)；2.黑龙江中医药大学附属第二医院科研基金项目(No. YM-201704)

Advance in Relationship between Autism Spectrum Disorders and Microbiome (review)

ZHANG Chun-yan^1,2, ZHU Lu-wen^1,2, TANG Qiang^1,2

1.Rehabilitation Medical College, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China
2.The Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China

Received:2019-01-15 Revised:2019-02-26 Published:2019-03-25 Online:2019-04-02
Contact: TANG Qiang, E-mail: tangqiang1963@163.com
Supported by:
Heilongjiang University of Chinese Medicine Project (No. 201517) and the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine Project (No. YM-201704)

摘要/Abstract

摘要： 随着微生物与大脑相互作用研究的深入，越来越多的科学家认识到肠道菌群对孤独症谱系障碍(ASD)患儿大脑和行为的重要性。目前，主要的研究集中于探究肠道微生物对ASD的致病机制。肠道微生物组与中枢神经系统的双向调节主要通过调节单胺类神经递质、下丘脑-垂体-肾上腺轴激活和神经免疫激活等途径来实现。微生物-肠-脑轴失衡可影响行为表型，导致ASD。因此，通过调节肠道微生物组来治疗ASD是今后的研究热点。本文对ASD肠道微生物组的研究现状进行总结，为肠道微生物组对神经心理的调控寻找更多的证据，以便能更好地理解微生物-肠-脑轴的潜在机制。

关键词: 孤独症谱系障碍, 微生物-肠-脑轴, 综述

Abstract: It has been increasingly recognized that the presence of a healthy and diverse gut microbiota is important to the development of central nervous system and emotional processing for children with autism spectrum disorders (ASD). The interconnection of gut microbiome and brain function has significantly contributed to establishing the microbiota-gut-brain axis as an extension of the well-accepted gut-brain axis concept. The bidirectional interaction between the gut microbiota and the brain occurs through various pathways including serotonin, hypothalamus-pituitary-adrenal axis, neurotrophin, and the immune system. The microbiota-gut-brain axis has been shown to influence the behaviors associated with neuropsychiatric conditions. Modulation of this gut microbiota as a novel therapy for ASD is gaining interest. This paper summarized the status of neuropsychological microbiome, which provided evidence supporting the role of gut microbiota in modulating neuropsychological functions of the central nervous system and exploring the potential underlying mechanisms.

Key words: autism spectrum disorders, microbiota-gut-brain axis, review

中图分类号:

R749.93

张春艳, 朱路文, 唐强. 肠道菌群与孤独症谱系障碍关系的研究进展[J]. 《中国康复理论与实践》, 2019, 25(3): 319-323.

ZHANG Chun-yan, ZHU Lu-wen, TANG Qiang. Advance in Relationship between Autism Spectrum Disorders and Microbiome (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(3): 319-323.

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肠道菌群与孤独症谱系障碍关系的研究进展

Advance in Relationship between Autism Spectrum Disorders and Microbiome (review)

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