儿童青少年抑郁症的脑电及影像学研究进展

doi:10.3969/j.issn.1006-9771.2018.00.014

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (3): 314-318.doi: 10.3969/j.issn.1006-9771.2018.00.014

儿童青少年抑郁症的脑电及影像学研究进展

安文军¹, 李金花², 王和平²

1.贵州师范学院教育科学学院，贵州贵阳市 550018
2.华东师范大学教育学部特殊教育学系，上海市 200062

收稿日期:2018-06-13 修回日期:2018-10-09 出版日期:2019-03-25 发布日期:2019-04-02
通讯作者: 王和平,E-mail: hpwang@spe.ecnu.edu.cn
作者简介:安文军(1990-)，男，土家族，贵州遵义市人，硕士，主要研究方向：特殊儿童康复与训练。通讯作者：王和平(1969-)，男，汉族，陕西榆林市人，硕士，副教授，主要研究方向：特殊儿童病理。

Advance in Electroencephalographic and Imaging Studies in Depression Children and Adolescents (review)

AN Wen-jun¹, LI Jin-hua², WANG He-ping²

1.School of Education Science, Guizhou Education University, Guiyang, Guizhou 550018, China
2.Special Education, Faculty of Education, East China Normal University, Shanghai 200062, China

Received:2018-06-13 Revised:2018-10-09 Published:2019-03-25 Online:2019-04-02
Contact: WANG He-ping, E-mail: hpwang@spe.ecnu.edu.cn

摘要/Abstract

摘要： 脑电研究、经颅多普勒(TCD)、磁共振、正电子发射断层扫描(PET)和单光子发射计算机断层成像术(SPECT)等在儿童青少年抑郁症的研究上取得一些积极成果。脑电研究发现，患者的α、β、δ和θ波以及事件相关电位(ERP)中的P300、P200、N100、N200等显著区别于常人，皮质激活区域不均衡；TCD、磁共振、PET和SPECT研究均发现，抑郁症患者额叶和颞叶等脑血流异常；磁共振研究发现，患者额叶、左侧梭状回、背前扣带皮质等脑结构和代谢异常，N-乙酰天冬氨酸盐、肌酸、胆碱和谷氨酸等可能是引起抑郁症发病的部分原因。

关键词: 儿童, 青少年, 抑郁症, 脑电图, 影像学, 综述

Abstract: tudies with electroencephalography, transcranial Doppler (TCD), magnetic resonance, positron emission tomography (PET), and single-photon emission computed tomography (SPECT) have achieved some positive results for depression in children and adolescents. Electroencephalographic studies found that the patients' α, β, δ, θ waves, and P300, P200, N100 and N200 in event-related potential (ERP) were significantly different from typical ones, and cortical activation area was uneven. TCD, magnetic resonance, PET and SPECT studies found that the patients with depression occurred cerebral blood flow abnormalities in frontal lobe and temporal lobe. Magnetic resonance studies found that there were brain structural and metabolic abnormalities in frontal lobe, left fusiform gyrus and anterior cingulate cortex, and N-acetyl aspartate, creatine, choline and glutamate might be a part of the cause of depression.

Key words: children, adolescents, depression, electroencephalography, imaging, review

中图分类号:

R749.94

安文军, 李金花, 王和平. 儿童青少年抑郁症的脑电及影像学研究进展[J]. 《中国康复理论与实践》, 2019, 25(3): 314-318.

AN Wen-jun, LI Jin-hua, WANG He-ping. Advance in Electroencephalographic and Imaging Studies in Depression Children and Adolescents (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(3): 314-318.

参考文献

1 高海青. 抑郁症与心血管疾病[J]. 山东医药, 2001, 41(18): 66-67.
2 MaughanB, CollishawS, StringarisA. Depression in childhood and adolescents [J]. J Can Acad Child Adolesc Psychiatry, 2013, 22(1): 35-40.
3 汪达山,王芳. 80例抑郁症的脑电图浅析[J]. 现代中西医结合杂志, 1997, 6(4): 552-553.
4 王萍. 抑郁症患者脑电图与经颅多普勒结果分析[J]. 中国伤残医学, 2012, 20(4): 83-84.
5 GrünewaldB D, GreimelE, TrinklM, et al. Resting frontal EEG asymmetry patterns in adolescents with and without major depression [J]. Biol Psychol, 2018, 132: 212.
6 廖智舟,李川,周军, 等. 抑郁症静息态脑电图前后部脑电活动[J]. 智能系统学报, 2014, 9(2): 168-173.
7 FengX, ForbesE E, KovacsM, et al. Children's depressive symptoms in relation to EEG frontal asymmetry and maternal depression [J]. J Abnorm Child Psychol, 2012, 40(2): 265-276.
8 KempA H, GriffithsK, FelminghamK L, et al. Disorder specificity despite comorbidity: resting EEG alpha asymmetry in major depressive disorder and post-traumatic stress disorder [J]. Biol Psychol, 2010, 85(2): 350-354.
9 JaworskaN, BlierP, FuseeW, et al. α power, α asymmetry and anterior cingulate cortex activity in depressed males and females [J]. J Psychiatr Res, 2012, 46(11): 1483-1491.
10 凃人顺,黄林英,陈仁波,等. 中医不同证候抑郁症的脑电地形图研究[J]. 世界中西医结合杂志, 2010, 5(5): 414-416.
11 王瑞青,李凌. 脑卒中后抑郁患者正负性情绪刺激后脑电地形图特点探究[J]. 精神医学杂志, 2017, 30(5): 350-353.
12 钱卫娟,刘刚,周群. 抑郁症患者脑电地形图改变对认知功能及与疗效的影响[J]. 中国健康心理学杂志, 2017, 25(10): 1441-1444.
13 LiM N, ZhengS J, NieJ R. An ERP study of emotional facial process in adolescents' peer attachment, anxiety and depression [J]. Ludong University Journal (Philosophy and Social Sciences Edition), 2017(5): 90-96.
14 GreimelE, TrinklM, BartlingJ, et al. Auditory selective attention in adolescents with major depression: An event-related potential study [J]. J Affect Disord, 2015, 172(2): 445-452.
15 FeldmannL, PiechaczekC E, PehlV, et al. State or Trait? Auditory event-related potentials in adolescents with current and remitted major depression [J]. Neuropsychologia, 2018, 113(5): 95-103.
16 BressJ N, MeyerA, HajcakG. Differentiating anxiety and depression in children and adolescents: evidence from event-related brain potentials [J]. J Clin Child Adolesc Psychol, 2015, 44(2): 238-249.
17 PuglisiV, BramantiA, LanzaG, et al. Impaired cerebral haemodynamics in vascular depression: insights from transcranial Doppler ultrasonography [J]. Front Psychiatry, 2018, 9(7): 316-320.
18 YuX Y, ZhengH B, MoZ B, et al. Analysis of test results of transcranial Doppler in patients with depression [J]. Prog Modern Biomed, 2013, 13(21): 4103-4106.
19 CullenK R, KlimesdouganB, MuetzelR, et al. Altered white matter microstructure in adolescents with major depression: a preliminary study [J]. J Am Acad Child Adolesc Psychiatry, 2010, 49(2): 173-183.
20 GuoW B, LiuF, XueZ M, et al. Altered white matter integrity in young adults with first-episode, treatment-naive, and treatment-responsive depression [J]. Neurosci Lett, 2012, 522(2): 139-144.
21 潘奋,黄满丽,许毅,等. 青少年抑郁症功能磁共振研究进展[J]. 国际精神病学杂志, 2017, 44(2): 211-213.
22 HoT C, ZhangS, SacchetM D, et al. Fusiform gyrus dysfunction is associated with perceptual processing efficiency to emotional faces in adolescent depression: a model-based approach [J]. Front Psychol, 2016, 7: 40. doi: 10.3389/fpsyg.2016.00040. eCollection 2016.
23 HendersonS E, VallejoA I, ElyB A, et al. The neural correlates of emotional face-processing in adolescent depression: a dimensional approach focusing on anhedonia and illness severity [J]. Psychiatry Res Neuroimaging, 2014, 224(3): 234-241.
24 BurkhouseK L, KujawaA, KeenanK, et al. The relation between parent depressive symptoms and neural correlates of attentional control in offspring: a preliminary study [J]. Psychiatry Res, 2017, 263: 26-31.
25 MaoN, FangJ, XieH, et al. Correlation between neurochemical metabolism and memory function in adolescent patients with depression: A multi-voxel 1H magnetic resonance spectroscopy study [J]. Psychiatry Clin Neurosci, 2016, 70(4): 167-174.
26 王滨,毛宁,刘泉源,等. 青少年抑郁症前额叶的磁共振波谱研究[J]. 实用医学杂志, 2014, 30(15): 2394-2397.
27 YangX R, LangevinL M, JaworskaN, et al. Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression [J]. Psychiatry Clin Neurosci, 2016, 70(7): 269-277.
28 TaylorM J, MannieZ N, NorburyR, et al. Elevated cortical glutamate in young people at increased familial risk of depression [J]. Int J Neuropsychopharmacol, 2011, 14(2): 255-259.
29 SavitzJ, NugentA C, CannonD M, et al. Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder [J]. Sci Rep, 2012, 2(3): 308-322.
30 PhillipsJ R, HewediD H, EissaA M, et al. The cerebellum and psychiatric disorders [J]. Front Public Health, 2015, 3: 66.
31 RichieriR, JouvenozD, VergerA, et al. Changes in dorsolateral prefrontal connectivity after rTMS in treatment-resistant depression: a brain perfusion SPECT study [J]. Eur J Nucl Med Mol Imaging, 2017, 44(6): 1051-1055.
32 高德九,金玉新. 抑郁症患者局部脑血流灌注SPECT显像的研究[J]. 陕西医学杂志, 2013, 42(8): 999-1001.
33 TongeB, KingN, KlimkeitE, et al. The Self-Efficacy Questionnaire for Depression in Adolescents (SEQ-DA). Development and psychometric evaluation [J]. Eur Child Adolesc Psychiatry, 2005, 14(7): 357-363.
34 HodgesK. Evaluation of Depression in Children and Adolescents Using Diagnostic Clinical Interviews [M]//Reynolds W M, Johnston H F. Handbook of Depression in Children and Adolescents. Issues in Clinical Child Psychology. Boston, MA: Springer, 1994: 183-208.
35 VitielloB, Ordó?ezA E. Pharmacological treatment of children and adolescents with depression [J]. Expert Opin Pharmacother, 2016, 17(17): 2273-2279.
36 OarE L, JohncoC, OllendickT H. Cognitive behavioral therapy for anxiety and depression in children and adolescents [J]. Psychiatr Clin North Am, 2017, 40(4): 661-674.
37 MerryS N, HetrickS E, CoxG R, et al. Psychological and educational interventions for preventing depression in children and adolescents [J]. Evid Based Child Health, 2012, 7(5): 1686-1688.

[1]	宋以玲, 任园春, 朱飞龙, 匡冬青, 曹庆久, 林杨, 王芳. 注意缺陷多动障碍儿童粗大动作技能与执行功能发展的特点及关系[J]. 《中国康复理论与实践》, 2024, 30(1): 1-9.
[2]	邵伟婷, 雷江华. 反应中断再定向干预孤独症谱系障碍儿童刻板语言的效果：Scoping综述[J]. 《中国康复理论与实践》, 2024, 30(1): 10-20.
[3]	罗丽华, 王雨生, 李剑锋, 董继革. 术后早期综合康复对儿童青少年肱骨髁上骨折伴尺神经损伤的效果[J]. 《中国康复理论与实践》, 2024, 30(1): 105-110.
[4]	郝传萍. 教育情境下辅助技术应用：政策架构与核心领域[J]. 《中国康复理论与实践》, 2024, 30(1): 119-124.
[5]	孙莹, 张强, 章鑫鑫, 王若晨. 视力障碍青少年心理韧性特点的质性研究[J]. 《中国康复理论与实践》, 2024, 30(1): 29-35.
[6]	王航宇, 葛可可, 范永红, 都丽露, 邹敏, 封磊. 基于ICD-11和ICF主动式音乐疗法改善认知障碍老年人认知功能的系统综述[J]. 《中国康复理论与实践》, 2024, 30(1): 36-43.
[7]	闻嘉宁, 金秋艳, 张琦, 李杰, 司琦. 认知参与型身体活动对发展儿童青少年执行功能的效果：基于ICF的系统综述[J]. 《中国康复理论与实践》, 2024, 30(1): 44-53.
[8]	葛可可, 范永红, 王航宇, 都丽露, 李长江, 邹敏. 失眠老年人正念干预健康效益的系统综述[J]. 《中国康复理论与实践》, 2024, 30(1): 54-60.
[9]	刘冬, 徐子涵, 李江, 鞠萍. M1区联合背外侧前额叶高频重复经颅磁刺激对脊髓损伤后神经病理性疼痛患者脑电图θ振幅的效果[J]. 《中国康复理论与实践》, 2024, 30(1): 87-94.
[10]	张婧雅, 邹敏, 孙宏伟, 孙昌隆, 朱峻同. 听障儿童青少年焦虑或抑郁情绪心理干预效果的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1004-1011.
[11]	王俊宇, 杨永, 袁逊, 谢婷, 庄洁. 高强度间歇训练对健康儿童青少年执行功能效果的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1012-1020.
[12]	魏晓微, 杨剑, 魏春艳. 特殊教育学校孤独症谱系障碍儿童参与适应性瑜伽活动的心理与行为效益的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1021-1028.
[13]	毕小羽, 朱笑彤, 朱飞龙, 匡冬青, 宋以玲, 范碧瑶, 任园春. 注意缺陷多动障碍学龄儿童精细动作技能的性别差异[J]. 《中国康复理论与实践》, 2023, 29(9): 1029-1034.
[14]	杨亚茹, 杨剑. 基于WHO-HPS架构学校身体活动相关健康服务及其健康效益：系统综述的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1040-1047.
[15]	史佳伟, 李凌宇, 杨浩杰, 王琴潞, 邹海欧. 预康复对全膝关节置换术后患者的有效性：系统综述的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1057-1064.

儿童青少年抑郁症的脑电及影像学研究进展

Advance in Electroencephalographic and Imaging Studies in Depression Children and Adolescents (review)

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

Metrics

本文评价

推荐阅读 0