经颅直流电刺激对老化和阿尔茨海默病认知功能影响的研究进展

doi:10.3969/j.issn.1006-9771.2019.03.002

《中国康复理论与实践》 ›› 2019, Vol. 25 ›› Issue (3): 255-260.doi: 10.3969/j.issn.1006-9771.2019.03.002

经颅直流电刺激对老化和阿尔茨海默病认知功能影响的研究进展

雷幸幸¹, 顾彬^1,2, 宋鲁平^1,2,3

1.首都医科大学康复医学院，北京市 100068
2.中国康复研究中心北京博爱医院，北京市 100068
3.神经损伤与康复北京市重点实验室，北京市 100068

收稿日期:2018-05-20 修回日期:2018-06-22 出版日期:2019-03-25 发布日期:2019-04-02
通讯作者: 宋鲁平，E-mail: songluping882002@aliyun.com
作者简介:雷幸幸(1995-)，女，汉族，河南洛阳市人，硕士研究生，主要研究方向：神经康复及认知神经科学。通讯作者：宋鲁平(1964-)，女，汉族，山东人，主任医师，教授，博士研究生导师，主要研究方向：神经康复及认知神经科学。
基金资助:
1.国家重点研发计划重点专项项目(No. 2016YFF0201002)；2.中央级公益性科研院所基本科研业务费专项资金项目(No. 2016CZ-6)

Effects of Transcranial Direct Current Stimulation on Cognitive Function after Aging and Alzheimer's Disease (review)

LEI Xing-xing¹, GU Bin^1,2, SONG Lu-ping^1,2,3

1.Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
2.Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
3.Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China

Received:2018-05-20 Revised:2018-06-22 Published:2019-03-25 Online:2019-04-02
Contact: SONG Lu-ping, E-mail: songluping882002@aliyun.com
Supported by:
National Key Research and Development Program (No. 2016YFF0201002) and National Special Fund Projects of Basic Research of Public Benefits for Institutes at Central Governmental Level (No. 2016CZ-6)

摘要/Abstract

摘要： 老化导致认知功能下降，包括记忆、注意、语言和执行等功能。阿尔茨海默病(AD)是一种与年龄密切相关的进行性神经退行性疾病，认知功能下降是其核心症状之一。经颅直流电刺激(tDCS)已被应用于健康老年人和AD患者，改善生理和病理性老化相关的认知障碍。tDCS能改善老年人的记忆(情景记忆、语义记忆和工作记忆)、语言、错误感知和注意功能，其效果受教育水平、刺激参数和个人任务基线成绩等多种因素影响。tDCS也能改善AD患者的认知功能，效果受解剖差异、疾病严重程度、刺激参数以及评估工具等因素影响。认知训练与tDCS结合可进一步增强老年人和AD患者认知功能。

关键词: 老化, 阿尔茨海默病, 经颅直流电刺激, 认知功能, 综述

Abstract: Aging leads to cognitive decline, including memory, attention, language and execution. Alzheimer's disease (AD) is a progressive neurodegenerative disorder closely related to age. Decreased cognitive function is one of its core symptoms. Transcranial direct current stimulation (tDCS) has been used in old healthy adults and AD patients to improve aging-related cognitive impairment. tDCS can improve memory (situational memory, semantic memory and working memory), language, error awareness and attentional functions in the old adults, which were influenced by many factors, such as education levels, stimulation parameters and individual task baseline scores, etc. For AD patients, tDCS may improve their cognitive function, which is influenced by the factors as anatomical differences, severity of disease, stimulation parameters and assessment tools, etc. Cognitive training combined with tDCS can further improve cognitive function in old adults and AD patients.

Key words: aging, Alzheimer's disease, transcranial direct current stimulation, cognitive function, review

中图分类号:

R749.1

雷幸幸, 顾彬, 宋鲁平. 经颅直流电刺激对老化和阿尔茨海默病认知功能影响的研究进展[J]. 《中国康复理论与实践》, 2019, 25(3): 255-260.

LEI Xing-xing, GU Bin, SONG Lu-ping. Effects of Transcranial Direct Current Stimulation on Cognitive Function after Aging and Alzheimer's Disease (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2019, 25(3): 255-260.

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经颅直流电刺激对老化和阿尔茨海默病认知功能影响的研究进展

Effects of Transcranial Direct Current Stimulation on Cognitive Function after Aging and Alzheimer's Disease (review)

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