神经肽Y受体系统参与痛觉调制的研究进展

doi:10.3969/j.issn.1006-9771.2018.00.006

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (11): 1284-1287.doi: 10.3969/j.issn.1006-9771.2018.00.006

神经肽Y受体系统参与痛觉调制的研究进展

赵舒煊^{1, 2}, 张东亮^{1, 2}, 沈伟^{1, 2}, 冯晓飞^{1, 2}, 刘正^{1, 2}, 袁文华^{1, 2}, 周海宇¹

1.兰州大学第二医院骨科,甘肃兰州市 730030;
2.甘肃省骨关节疾病研究重点实验室,甘肃兰州市 730030

收稿日期:2018-07-13 修回日期:2018-08-01 出版日期:2018-11-20 发布日期:2018-12-26
通讯作者: 周海宇。E-mail: zhouhy@lzu.edu.cn
作者简介:赵舒煊(1992-),男,汉族,甘肃敦煌市人,硕士研究生,主要研究方向：脊柱脊髓损伤的康复与治疗。
基金资助:
甘肃省自然科学基金项目(No. 17JR5RA189)

Advance in Role of Neuropeptide Y Receptors System in Pain Modulation (review)

ZHAO Shu-xuan^{1, 2}, ZHANG Dong-liang^{1, 2}, SHEN Wei^{1, 2}, FENG Xiao-fei^{1, 2}, LIU Zheng^{1, 2}, YUAN Wen-hua^{1, 2}, ZHOU Hai-yu¹

1. Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China;
2. Key Laboratory of Bone and Joint Diseases of Gansu Province, Lanzhou, Gansu 730030, China

Received:2018-07-13 Revised:2018-08-01 Published:2018-11-20 Online:2018-12-26
Contact: ZHOU Hai-yu. E-mail: zhouhy@lzu.edu.cn
Supported by:
Supported by Natural Science Foundation of Gansu Province (No. 17JR5RA189)

摘要/Abstract

摘要： 神经肽Y受体系统是由神经肽Y (NPY)及其哺乳动物体内特异性受体组成的受体-配体系统,广泛参与哺乳动物内痛觉调制,以Y1受体(Y1R)和Y2受体(Y2R)两类亚型为代表。此类受体属G蛋白偶联受体,参与神经元膜信号转导,在中枢神经系统痛觉相关区域广泛分布,不同受体在颅内和脊髓水平分布具有特异性。NPY通过与Y1R和Y2R结合,维持痛觉传递过程的稳态。其中,脊髓水平结合Y1R可发挥镇痛效用,结合Y2R通常可发挥促痛作用。颅内调制功能则与特定区域核团功能有关。

关键词: 神经肽Y, 受体, 痛觉调制, 综述

Abstract: The neuropeptide Y receptors system is a receptor-ligand system composed of neuropeptide Y and its receptors, which is represented by two subtypes, including Y1 receptor (Y1R) and Y2 receptor (Y2R). The system is widely involved in pain modulation in mammals. These receptors are G protein-coupled receptors, participating in neuronal membrane signaling. Neuropeptide Y receptors distribute in the pain-related regions of the central nervous system, play a variety of roles in maintains neuronal activity of pain transmission, relate to the specificity of distribution. At the spinal level, Y1R plays an analgesic role, whereas Y2R is usually related to pain-promoting. The system can also take part in cerebral pain modulation at different nuclei.

Key words: neuropeptide Y, receptors, pain modulation, review

中图分类号:

R741.02

赵舒煊, 张东亮, 沈伟, 冯晓飞, 刘正, 袁文华, 周海宇. 神经肽Y受体系统参与痛觉调制的研究进展[J]. 《中国康复理论与实践》, 2018, 24(11): 1284-1287.

ZHAO Shu-xuan, ZHANG Dong-liang, SHEN Wei, FENG Xiao-fei, LIU Zheng, YUAN Wen-hua, ZHOU Hai-yu. Advance in Role of Neuropeptide Y Receptors System in Pain Modulation (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(11): 1284-1287.

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神经肽Y受体系统参与痛觉调制的研究进展

Advance in Role of Neuropeptide Y Receptors System in Pain Modulation (review)

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