经颅直流电刺激治疗帕金森病认知障碍的研究进展

doi:10.3969/j.issn.1006-9771.2018.07.005

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (7): 773-778.doi: 10.3969/j.issn.1006-9771.2018.07.005

经颅直流电刺激治疗帕金森病认知障碍的研究进展

顾彬^{1, 2}, 王强^{1, 2, 3}, 雷幸幸¹, 宋鲁平^{1, 2, 3}

1.首都医科大学康复医学院,北京市 100068;
2.中国康复研究中心北京博爱医院,北京市 100068;
3.神经损伤与康复北京市重点实验室,北京市 100068

收稿日期:2018-05-21 修回日期:2018-06-22 出版日期:2018-07-25 发布日期:2018-08-01
通讯作者: 宋鲁平。E-mail: songluping882002@aliyun.com
作者简介:顾彬(1986-),男,汉族,山东滨州市人,硕士研究生,治疗师,主要研究方向：神经康复、认知神经科学、作业治疗。通讯作者：宋鲁平(1964-),女,汉族,山东人,主任医师、教授,博士研究生导师,主要研究方向：神经康复、认知神经科学。
基金资助:
1.国家重点研发计划(No. 2016YFF0201002); 2.中央级公益性科研院所基本科研业务费专项资金项目(No. 2016CZ-6)

Advance in Transcranial Direct Current Stimulation for Cognitive Impairment in Parkinson's Disease (review)

GU Bin^{1, 2}, WANG Qiang^{1, 2, 3}, LEI Xing-xing¹, SONG Lu-ping^{1, 2, 3}

1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China;
2. Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China;
3. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China

Received:2018-05-21 Revised:2018-06-22 Published:2018-07-25 Online:2018-08-01
Contact: SONG Lu-ping. E-mail: songluping882002@aliyun.com

摘要/Abstract

摘要： 认知障碍是帕金森病最常见的非运动症状,可能与神经递质改变、皮质萎缩、异常蛋白沉积等有关,严重影响患者运动功能和日常生活活动能力。经颅直流电刺激可改变皮质兴奋性、影响脑区局部血流量、改变突触性能,开始应用于帕金森病认知障碍的康复治疗。

关键词: 帕金森病, 认知障碍, 经颅直流电刺激, 康复, 综述

Abstract: Cognitive impairment is the most common non-motor symptom of Parkinson's disease (PD), which may associate with the disorders of transmitters, cortical atrophy, proteinosis, etc., and seriously influence the motor function, ability of daily life of the patients. Transcranial direct current stimulation (tDCS), which may adjust the cerebral excitability, regional blood flow, plasticity of synapses, etc., has been used for PD cognitive impairment.

Key words: Parkinson's disease, cognitive impairment, transcranial direct current stimulation, rehabilitation, review

中图分类号:

R742.5

顾彬, 王强, 雷幸幸, 宋鲁平. 经颅直流电刺激治疗帕金森病认知障碍的研究进展[J]. 《中国康复理论与实践》, 2018, 24(7): 773-778.

GU Bin, WANG Qiang, LEI Xing-xing, SONG Lu-ping. Advance in Transcranial Direct Current Stimulation for Cognitive Impairment in Parkinson's Disease (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(7): 773-778.

参考文献

[1] 高中宝,王洁,王炜,等. 帕金森病诊断与治疗新进展[J]. 中国现代神经疾病杂志, 2015, 15(10): 777-781.
[2] Yarnall AJ, Breen DP, Duncan GW, et al.Characterizing mild cognitive impairment in incident Parkinson disease The ICICLE-PD Study[J]. Neurology, 2014, 82(4): 308-316.
[3] Cappon D, Jahanshahi M, Bisiacchi P.Value and efficacy of transcranial direct current stimulation in the cognitive rehabilitation: a critical review since 2000[J]. Front Neurosci, 2016, 10(180): 157.
[4] Miyasaki JM, Kluger B.Palliative care for Parkinson's disease: has the time come?[J]. Curr Neurol Neurosci Rep, 2015, 15(5): 26.
[5] Litvan I, Aarsland D, Adler CH, et al.MDS task force on mild cognitive impairment in Parkinson's disease: critical review of PD-MCI[J]. Mov Disord, 2011, 26(10): 1814-1824.
[6] Peruzzotti-Jametti L, Bacigaluppi M, Sandrone S, et al.Emerging subspecialties in neurology: transcranial stimulation[J]. Neurology, 2013, 80(4): e33.
[7] Hely MA, Morris JG, Reid WG, et al.Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years[J]. Mov Disord, 2005, 20(2): 190.
[8] Aarsland D, Brønnick K, Fladby T.Mild cognitive impairment in Parkinson's disease[J]. Curr Neurol Neurosci, 2011, 11(4): 371-378.
[9] Galtier I, Nieto A, Lorenzo JN, et al.Mild cognitive impairment in Parkinson's disease: diagnosis and progression to dementia[J]. J Clin Exp Neuropsychol, 2016, 38(1): 40-50.
[10] Monastero R, Cicero CE, Baschi R, et al.Mild cognitive impairment in Parkinson's disease: the Parkinson's Disease Cognitive Study (PACOS)[J]. J Neurol, 2018(suppl 8): 1-9.
[11] 吴晓宇,曹丽,黎西,等. 并存非运动症状的帕金森病患者轻度认知功能障碍发生情况及危险因素分析[J]. 脑与神经疾病杂志, 2017, 25(10): 623-626.
[12] Sanjari MH, Zareshahabadi A, Rahmani F, et al.Neurotransmission systems in Parkinson's disease[J]. Rev Neurosci, 2017, 28(5): 509-536.
[13] 唐毅,纪笑娟,邢怡,等. 帕金森病痴呆与阿尔茨海默病的认知和精神行为症状比较[J]. 中华医学杂志, 2013, 93(31): 2459-2462.
[14] Hirsch EC, Jenner P, Przedborski S.Pathogenesis of Parkinson's disease[J]. Mov Disord, 2013, 28(1): 24-30.
[15] 佟晴,袁永胜,徐勤荣,等. 帕金森病伴发抑郁患者血浆谷氨酸和γ-氨基丁酸水平的改变及其临床意义[J]. 中国神经精神疾病杂志, 2015, 41(4): 224-228.
[16] Tong Q, Xu Q, Xia Q, et al.Correlations between plasma levels of amino acids and nonmotor symptoms in Parkinson's disease[J]. J Neural Transm, 2015, 122(3): 411.
[17] 胡晓飞,张久权,张艳玲,等. 基于体素形态学观察帕金森病患者全脑灰质:2年纵向MR研究[J]. 中国医学影像技术, 2013, 29(7): 1076-1080.
[18] 马红蕾,白星宇,卜范艳. 帕金森病患者的认知功能与MRI变化的相关性分析[J]. 中外医疗, 2017, 36(7): 22-25.
[19] Song SK, Lee JE, Park HJ, et al.The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status[J]. Mov Disord, 2011, 26(2): 289-296.
[20] Duncan GW, Firbank MJ, Yarnall AJ, et al.Gray and white matter imaging: a biomarker for cognitive impairment in early Parkinson's disease?[J]. Mov Disord, 2016, 31(1): 103-110.
[21] 邱雨. 神经变性疾病的朊蛋白样作用机制研究进展[J]. 国际神经病学神经外科学杂志, 2016, 43(6): 560-563.
[22] 谷星忠,石志鸿,郭宏,等. 路易体痴呆与帕金森病痴呆认知及精神行为比较[J]. 实用医学杂志, 2017, 33(23): 3876-3879.
[23] Braak H, Rüb U, Jansen Steur EN, et al.Cognitive status correlates with neuropathologic stage in Parkinson disease[J]. Neurology, 2005, 64(8): 1404-1410.
[24] Murakami H, Momma Y, Nohara T, et al.Improvement in language function correlates with gait improvement in drug-naïve Parkinson's disease patients taking dopaminergic medication[J]. J Parkinsons Dis, 2016, 6(1): 752-756.
[25] Lawson RA, Yarnall AJ, Duncan GW, et al.Severity of mild cognitive impairment in early Parkinson's disease contributes to poorer quality of life[J]. Parkinsonism Relat Disord, 2014, 20(10): 1071-1075.
[26] 王圣龙,唐金荣. 帕金森病患者伴发认知障碍与非运动症状的相关性研究[J]. 实用临床医药杂志, 2016, 20(21): 17-20.
[27] 吴春薇,谢瑛. 经颅直流电刺激的研究进展[J]. 中国康复理论与实践, 2015, 21(2): 171-175.
[28] Dutta A, Jacob A, Chowdhury SR, et al.EEG-NIRS based assessment of neurovascular coupling during anodal transcranial direct current stimulation–a stroke case series[J]. J Med Syst, 2015, 39(4): 205.
[29] Williams JA, Pascual-Leone A, Fregni F.Interhemispheric modulation induced by cortical stimulation and motor training[J]. Phys Ther, 2010, 90(3): 398-410.
[30] Kraft A, Roehmel J, Olma MC, et al.Transcranial direct current stimulation affects visual perception measured by threshold perimetry[J]. Exp Brain Res, 2010, 207(3-4): 283-290.
[31] Batsikadze G, Moliadze V, Paulus W, et al.Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans[J]. J Physiol, 2013, 591(7): 1987-2000.
[32] Boggio PS, Ferrucci R, Rigonatti SP, et al.Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease[J]. J Neurol Sci, 2006, 249(1): 31-38.
[33] Manenti R, Brambilla M, Rosini S, et al.Time up and go task performance improves after transcranial direct current stimulation in patient affected by Parkinson's disease[J]. Neurosci Lett, 2014, 580: 74-77.
[34] Doruk D, Gray Z, Bravo GL, et al.Effects of tDCS on executive function in Parkinson's disease[J]. Neurosci Lett, 2014, 582: 27-31.
[35] Knotkova H, Portenoy RK, Cruciani RA.Transcranial direct current stimulation (tDCS) relieved itching in a patient with chronic neuropathic pain[J]. Clin J Pain, 2013, 29(7): 621-622.
[36] Dutta A, Chowdhury SR, Das A.Electroencephalography-near-infrared spectroscopy based assessment of neurovascular effects under transcranial direct current stimulation–a stroke case series[J]. Brain Stimul, 2015, 8(2): 322.
[37] Merzagora AC, Foffani G, Panyavin I, et al.Prefrontal hemodynamic changes produced by anodal direct current stimulation[J]. Neuroimage, 2010, 49(3): 2304-2310.
[38] Feng WW, Bowden MG, Kautz S.Review of transcranial direct current stimulation in poststroke recovery[J]. Top Stroke Rehabil, 2013, 20(1): 68-77.
[39] Rizzo V, Terranova C, Crupi D, et al.Increased transcranial direct current stimulation after effects during concurrent peripheral electrical nerve stimulation[J]. Brain Stimul, 2014, 7(1): 113-121.
[40] Koops S, van den Brink H, Sommer IE. Transcranial direct current stimulation as a treatment for auditory hallucinations[J]. Front Psychol, 2015, 6: 244.
[41] Kuo MF, Paulus W, Nitsche MA.Therapeutic effects of non-invasive brain stimulation with direct currents (tDCS) in neuropsychiatric diseases[J]. Neuroimage, 2014, 85(2): 948-960.
[42] Fregni F, Boggio PS, Santos MC, et al.Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease[J]. Mov Disord, 2006, 21(10): 1693-1702.
[43] Benninger DH, Lomarev M, Lopez G, et al.Transcranial direct current stimulation for the treatment of Parkinson's disease[J]. J Neurol Neurosurg, 2010, 81(10): 1105.
[44] Schabrun SM, Lamont RM, Brauer SG.Transcranial direct current stimulation to enhance dual-task gait training in Parkinson's disease: a pilot RCT[J]. PLoS One, 2016, 11(6): e158497.
[45] Ferrucci R, Cortese F, Bianchi M, et al.Cerebellar and motor cortical transcranial stimulation decrease levodopa-induced dyskinesias in Parkinson's disease[J]. Cerebellum, 2016, 15(1): 43-47.
[46] Swank C, Mehta J, Criminger C.Transcranial direct current stimulation lessens dual task cost in people with Parkinson's disease[J]. Neurosci Lett, 2016, 626: 1-5.
[47] Salimpour Y, Mari ZK, Shadmehr R.Altering effort costs in Parkinson's disease with noninvasive cortical stimulation[J]. J Neurosci, 2015, 35(35): 12287-12302.
[48] Manenti R, Brambilla M, Benussi A, et al.Mild cognitive impairment in Parkinson's disease is improved by transcranial direct current stimulation combined with physical therapy[J]. Mov Disord, 2016, 31(5): 715-724.
[49] Pereira JB, Junqué C, Bartrés-Faz D, et al.Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson's disease[J]. Brain Stimul, 2013, 6(1): 16-24.
[50] Forogh B, Rafiei M, Arbabi A, et al.Repeated sessions of transcranial direct current stimulation evaluation on fatigue and daytime sleepiness in Parkinson's disease[J]. Neurol Sci, 2016, 38(2): 1-6.
[51] 吴东川,吴晓霞,王广君,等. 多巴丝肼片口服联合经颅直流电刺激对帕金森病患者非运动症状的改善作用[J]. 山东医药, 2016, 56(31): 88-90.
[52] 王广君,赵振华,吴东川,等. 经颅直流电刺激对帕金森病非运动症状的疗效[J]. 中国医药导报, 2016, 13(5): 75-78.
[53] Guell X, Gabrieli J, Schmahmann JD.Triple representation of language, working memory, social and emotion processing in the cerebellum: convergent evidence from task and seed-based resting-state fMRI analyses in a single large cohort[J]. Neuroimage, 2018, 172: 437-449.
[54] 俞雪鸿,田学隆,李一言,等. 重复经颅直流电刺激帕金森病模型大鼠的旋转行为[J]. 中国组织工程研究, 2012, 16(24): 4471-4475.
[55] Poreisz C, Boros K, Antal A, et al.Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients[J]. Brain Res Bull, 2007, 72(6): 208-214.
[56] Nitsche MA, Niehaus L, Hoffmann KT, et al.MRI study of human brain exposed to weak direct current stimulation of the frontal cortex[J]. Clin Neurophysiol, 2004, 115(10): 2419-2423.
[57] Zhao H, Qiao L, Fan D, et al.Modulation of brain activity with noninvasive transcranial direct current stimulation (tDCS): clinical applications and safety concerns[J]. Front Psychol, 2017, 685(8): 1-17

经颅直流电刺激治疗帕金森病认知障碍的研究进展

Advance in Transcranial Direct Current Stimulation for Cognitive Impairment in Parkinson's Disease (review)

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