近红外脑功能成像对卒中后抑郁神经机制的研究

doi:10.3969/j.issn.1006-9771.2017.00.003

《中国康复理论与实践》 ›› 2018, Vol. 24 ›› Issue (4): 427-431.doi: 10.3969/j.issn.1006-9771.2017.00.003

近红外脑功能成像对卒中后抑郁神经机制的研究

李泓钰¹, 王强^{1, 2, 3}, 杜晓霞^{1, 2, 3}, 王静⁴, 徐舒¹, 王曼¹, 宋鲁平^{1, 2, 3}

1.首都医科大学康复医学院,北京市 100068;
2.中国康复研究中心北京博爱医院,北京市 100068;
3.神经损伤与康复北京市重点实验室,北京市 100068;
4.首都医科大学基础医学院,北京市 100069

收稿日期:2017-12-05 修回日期:2017-12-14 出版日期:2018-04-25 发布日期:2018-04-27
通讯作者: 宋鲁平(1964-),女,汉族,山东人,主任医师,教授,博士研究生导师,主要研究方向：神经康复、认知神经科学。E-mail: songluping882002@aliyun.com
作者简介:李泓钰(1993-),女,汉族,甘肃兰州市人,硕士研究生,主要研究方向：神经康复、认知神经科学。
基金资助:
1.中央级公益性科研院所基本科研业务费专项资金项目(No. 2016CZ-6); 2.中国康复研究中心项目(No. 2017ZX- 12)

Neural Mechanism of Post-stroke Depression: A Functional Near-infrared Spectroscopy Study

LI Hong-yu¹, WANG Qiang^{1, 2, 3}, DU Xiao-xia^{1, 2, 3}, WANG Jing⁴, XU Shu¹, WANG Man¹, SONG Lu-ping^{1, 2, 3}

1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068,China;
2. Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China;
3. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing 100068, China;
4. Capital Medical University School of Basic Medical Sciences, Beijing 100069, China

Received:2017-12-05 Revised:2017-12-14 Published:2018-04-25 Online:2018-04-27
Contact: SONG Lu-ping. E-mail: songluping882002@aliyun.com

摘要/Abstract

摘要： 目的观察卒中后抑郁(PSD)患者在认知加工期间前额叶氧合血红蛋白(Oxy-Hb)相对浓度变化值,初步探讨PSD的神经机制和工作记忆功能变化。方法 2017年2月至8月,20例PSD患者(PSD组)及20例卒中非抑郁患者(对照组),应用NIRSport便携式近红外脑功能成像系统,分别采用情绪面孔性别判断任务和“1-back”工作记忆任务,观察前额叶Oxy-Hb相对浓度变化值。结果在负性情绪面孔图片呈现后,PSD组前额叶Oxy-Hb相对浓度变化值显著低于对照组(t=3.872, P<0.001)。在“1-back”工作记忆任务时,PSD组左侧前额叶Oxy-Hb相对浓度变化值低于对照组(t=2.475, P=0.018),两组右侧前额叶Oxy-Hb相对浓度变化值无显著性差异(t=1.773, P=0.084)。结论 PSD患者在负性情绪面孔图片呈现后,前额叶激活程度降低,并且左侧前额叶工作记忆功能受损,PSD患者前额叶有氧代谢功能失调。

关键词: 卒中后抑郁, 近红外脑功能成像, 前额叶, 神经机制, 工作记忆

Abstract: Objective To observe the change of the relative concentration of oxygenated hemoglobin in the frontal cortex during cognitive processing in patients with post-stroke depression (PSD), and to discuss the neural mechanism and changes of working memory function of PSD preliminarily.Methods From February to August, 2017, 20 patients with PSD (PSD group) and 20 patients with non-depressive (control group) were recruited. NIRSport portable functional near-infrared spectroscopy system was used to observe the change of the relative concentration of hemoglobin in the frontal cortex during the emotional face gender judgment task and "1-back" working memory task. Results Compared with the control group, the change of the relative concentration of oxygenated hemoglobin in the prefrontal cortex was significantly lower after the negative emotion faces were presented in PSD group (t=3.872, P<0.001). In the implementation of the "1-back", the change of the relative concentration of oxygenated hemoglobin in the left prefrontal cortex was significantly lower in PSD group than in the control group (t=2.475, P<0.05), however, there was no significant difference in the change in the right prefrontal cortex between two groups (t=1.773, P=0.084).Conclusion The prefrontal cortex activity decrease in patients with PSD after the negative emotion faces were presented. The left prefrontal working memory function is impaired. The patients with PSD have disorder of oxygen metabolism in the prefrontal lobe.

Key words: post-stroke depression, functional near-infrared spectroscopy, frontal cortex, neural mechanism, working memory

中图分类号:

R743.3

李泓钰, 王强, 杜晓霞, 王静, 徐舒, 王曼, 宋鲁平. 近红外脑功能成像对卒中后抑郁神经机制的研究[J]. 《中国康复理论与实践》, 2018, 24(4): 427-431.

LI Hong-yu, WANG Qiang, DU Xiao-xia, WANG Jing, XU Shu, WANG Man, SONG Lu-ping. Neural Mechanism of Post-stroke Depression: A Functional Near-infrared Spectroscopy Study[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2018, 24(4): 427-431.

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近红外脑功能成像对卒中后抑郁神经机制的研究

Neural Mechanism of Post-stroke Depression: A Functional Near-infrared Spectroscopy Study

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