中药治疗化疗所致周围神经病变的效果

doi:10.3969/j.issn.1006-9771.2017.11.017

《中国康复理论与实践》 ›› 2017, Vol. 23 ›› Issue (11): 1321-1325.doi: 10.3969/j.issn.1006-9771.2017.11.017

中药治疗化疗所致周围神经病变的效果

李元青, 孙红, 薛冬, 李占东, 许轶琛, 王薇, 李萍萍

北京大学肿瘤医院暨北京市肿瘤防治研究所,恶性肿瘤发病机制及转化研究教育部重点实验室,北京市 100142

收稿日期:2017-03-12 出版日期:2017-11-25 发布日期:2017-12-10
通讯作者: 李萍萍(1951-),女,汉族,硕士,教授,主任医师,博士生研究生导师,主要研究方向：恶性肿瘤中西医结合治疗及肿瘤症状控制。E-mail: lppma123@sina.com。
作者简介:李元青(1975-),女,汉族,青海西宁市人,博士,主治医师,主要研究方向：老年肿瘤及肿瘤治疗相关不良反应的中西医结合治疗。

Effects of Chinese Medicine on Chemotherapy-induced Peripheral Neuropathy: A Randomized, Double-blind, Placebo-controlled Clinical Trial

LI Yuan-qing, SUN Hong, XUE Dong, LI Zhan-dong, XU Yi-chen, WANG Wei, LI Ping-ping

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese Medicine and Western Medicine & Geriatric Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China

Received:2017-03-12 Published:2017-11-25 Online:2017-12-10
Contact: LI Ping-ping. E-mail: lppma123@sina.com

摘要/Abstract

摘要： 目的观察中药减轻化疗所致周围神经病变及提高患者生活质量的疗效。方法 2013年4月至2014年12月,56例患者盲法随机均分为对照组和干预组,干预组采用黄芪桂枝五物汤合身痛逐瘀汤加减颗粒剂,对照组采用安慰颗粒剂,共治疗1个月。治疗前、治疗后4周、治疗后8周、治疗后12周,采用数字分级量表(NRS)评定其主要症状严重程度,采用美国国立癌症研究所常见不良反应事件术语评价标准(NCI-CTCAE) 4.0版评估周围神经毒性分级,采用欧洲癌症研究与治疗组织生活质量量表(EORTC QLQ-C30)评估生活质量。结果治疗后8周和12周,干预组NRS评分较对照组明显改善(F>9.518, P<0.01),NCI-CTCAE分级提高(Z>3.887, P<0.05);治疗后12周,EORTC QLQ-C30疲乏评分明显下降(t=-2.971, P<0.01)。结论中药能改善化疗所致周围神经病变的症状,降低神经毒性分级,对生活质量的改善可能有些帮助。

关键词: 周围神经病变, 化学疗法, 中药, 黄芪桂枝五物汤, 身痛逐瘀汤

Abstract: Objective To investigate the efficacy of a Chinese Medicine formula on chemotherapy-induced peripheral neuropathy (CIPN).Methods From April, 2013 to December, 2014, 56 patients were randomized blindly to receive granulas of Chinese Medicine of modified Huangqi-Guizhi Wuwu and Shentong-Zhuyu (treatment group, n=28) or placebo (control group, n=28), for a month. They were assessed with Number Rating Scale (NRS) of symptoms of CIPN, National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 4.0, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-30 (EORTC QLQ-C30) before, and four weeks, eight weeks and twelve weeks after treatment.Results The score of NRS (F>9.518, P<0.01)and grade of NCI-CTCAE (Z>3.887, P<0.05) improved in the treatment group compared with those in the control group eight weeks and twelve weeks after treatment. The scores of EORTC QLQ-C30 also improved twelve weeks after treatment, but only significantly in the symptom of fatigue (t=-2.971, P<0.01).Conclusion The Chinese Medicine can release the symptoms of CIPN, decrease the grade of neurotoxicity, and may improve the quality of life somewhat.

Key words: peripheral neuropathy, chemotherapy, Chinese Medicine, Huangqi-Guizhi-Wuwu Decoction, Shentong-Zhuyu Decoction

中图分类号:

R730.6

李元青, 孙红, 薛冬, 李占东, 许轶琛, 王薇, 李萍萍. 中药治疗化疗所致周围神经病变的效果[J]. 《中国康复理论与实践》, 2017, 23(11): 1321-1325.

LI Yuan-qing, SUN Hong, XUE Dong, LI Zhan-dong, XU Yi-chen, WANG Wei, LI Ping-ping. Effects of Chinese Medicine on Chemotherapy-induced Peripheral Neuropathy: A Randomized, Double-blind, Placebo-controlled Clinical Trial[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(11): 1321-1325.

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中药治疗化疗所致周围神经病变的效果

Effects of Chinese Medicine on Chemotherapy-induced Peripheral Neuropathy: A Randomized, Double-blind, Placebo-controlled Clinical Trial

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