《中国康复理论与实践》

《中国康复理论与实践》 ›› 2002, Vol. 8 ›› Issue (01): 11-12.

• 基础研究 • 上一篇    下一篇

新骨生胶囊治疗股骨头坏死的药理研究

左萍萍; 吴业华; 李学坤   

  1. 中国医学科学院,中国协和医科大学基础医学院药理室 北京市 100005
  • 收稿日期:2001-08-15 出版日期:2002-01-25 发布日期:2002-01-25

Experimental study of the treatment of Xingusheng(XGS) Capsule on the femoral head necrosis in mouse and rat

ZUO Ping-ping,WU Ye-hua, LI Xue-kun   

  1. Department of Pharmacology, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100005, China
  • Received:2001-08-15 Published:2002-01-25 Online:2002-01-25

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被引次数

42

摘要： 目的探讨中药新骨生胶囊治疗无菌性股骨头坏死的机理。方法采用口服维甲酸致小鼠和大鼠骨质变性模型。30只昆明小鼠分为3组,未服药者作为正常组(10只),模型组(10只)和治疗组(10只)均服维甲酸,治疗组同时服新骨生胶囊,观察时间为3周。18只Wistar大鼠分为3组,未服药者为正常组(6只),模型组(6只)和治疗组(6只)切除睾丸,并服维甲酸,治疗组同时服新骨生胶囊,观察5周。观察小鼠自发活动变化,用双能X线检测大鼠的骨密度,并用HE染色观察病理改变。结果小鼠模型自发运动(横向和纵向)明显减少(P<0.01);模型大鼠平均骨密度、股骨重量及重量系数明显低于正常组(P<0.01)。病理切片可见股骨头关节软骨表层有缺损、骨化线紊乱、骨小梁变细 ,出现死骨。经新骨生胶囊治疗 5周后 ,治疗组与正常组相比未见显著性差异。结论新骨生胶囊具有促进骨质修复的作用。

关键词: 新骨生胶囊, 中药, 股骨头坏死, 骨密度, 骨质修复

Abstract: ObjectiveTo study the effect of XGS Capsule on the femoral head necrosis in mouse and rat. MethodsThe animal model of femoral head necrosis was caused with tretinoin per os. The free locomotive activity, bone density and pathological changed were observed. ResultsIn the model mouse, the free locomotive activity decreased significantly(P<0.01). In the model rat, the density and weight of the bone also decreased(P<0.01). The defects of cartilage, disorders of ossification and dead bone were observed in the femoral head joint. After treatment with XGS Capsule for 5 weeks, these pathological changes significantly improved. Conclusions XGS Capsule was effective in treating the femoral head necrosis.

Key words: Xingusheng Capsule, Chinese herbs, necrosis of femoral head, bone density, bone repair