肥胖性肌肉萎缩的分子机制研究进展

doi:10.3969/j.issn.1006-9771.2017.05.013

《中国康复理论与实践》 ›› 2017, Vol. 23 ›› Issue (5): 553-557.doi: 10.3969/j.issn.1006-9771.2017.05.013

肥胖性肌肉萎缩的分子机制研究进展

罗琳^1,2, 杨金鹏³, 王松涛⁴, 廖欣⁵, 詹玮⁵

1.贵州师范大学体育学院,贵州贵阳市 550001;
2.北京体育大学运动人体科学学院,北京市 100084;
3.解放军信息工程大学指挥军官基础教育学校,河南郑州市 450001;
4.华南师范大学体育科学学院,广东广州市 510006;
5.贵州医科大学附属医院,贵州贵阳市 550001。

收稿日期:2016-12-09 修回日期:2017-01-16 出版日期:2017-05-25 发布日期:2017-05-24
作者简介:罗琳(1979-),女,汉族,贵州贵阳市人,博士,副教授,主要研究方向：运动与骨骼肌代谢。E-mail: 5925860@qq.com。
基金资助:
1.贵州省教育厅青年科技人才成长项目(No.黔教合KY字[2016]129); 2.中央高校基本科研业务费资助北京体育大学自主课题(No.2016BS026)

Advances of Molecular Mechanisms on Obesity Inducing Muscle Atrophy (review)

LUO Lin^1,2, YANG Jin-peng³, WANG Song-tao⁴, LIAO Xin⁵, ZHAN Wei⁵

1. Guizhou Normal University, Guiyang, Guizhou 550001, China;
2. Beijing Sport University, Beijing 100084, China;
3. The PLA Information Engineering University, Zhengzhou, Henan 450001, China;
4. South China Normal University, Guangzhou, Gguangdong 510006, China;
5. The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, China

Received:2016-12-09 Revised:2017-01-16 Published:2017-05-25 Online:2017-05-24
Contact: LUO Lin. E-mail: 5925860@qq.com

摘要/Abstract

摘要： 肥胖正成为全球范围内的慢性流行病。持续肥胖状态,可能引起泛素蛋白酶、自噬作用、瘦素、脂联素、白细胞介素6、白细胞介素10、肿瘤坏死因子α、生长激素、血管紧张素Ⅱ、糖皮质激素、高级糖化终产物和肌肉生长抑制素等分子介导信号通路发生改变,进而调节肌肉代谢,引发肌肉萎缩。

关键词: 肥胖, 肌肉萎缩, 信号通路, 综述

Abstract: Obesity is becoming a chronic epidemic worldwide. Persistent obesity, in addition to triggering changes in skeletal muscle function and structure, may also lead to the occurrence of skeletal muscle atrophy, that maybe associate with autophagy and ubiquitin proteasome, interleukin-6, leptin, adiponectin, interleukin-10, tumor necrosis factor-alpha, growth hormone, angiotensin II, glucocorticoid, advanced glycation end-product and myostatin, etc.

Key words: obesity, muscle atrophy, signal pathway, review

中图分类号:

R589.2

罗琳, 杨金鹏, 王松涛, 廖欣, 詹玮. 肥胖性肌肉萎缩的分子机制研究进展[J]. 《中国康复理论与实践》, 2017, 23(5): 553-557.

LUO Lin, YANG Jin-peng, WANG Song-tao, LIAO Xin, ZHAN Wei. Advances of Molecular Mechanisms on Obesity Inducing Muscle Atrophy (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(5): 553-557.

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肥胖性肌肉萎缩的分子机制研究进展

Advances of Molecular Mechanisms on Obesity Inducing Muscle Atrophy (review)

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