散乱蛋白对神经发生影响的研究进展

doi:10.3969/j.issn.1006-9771.2017.05.012

摘要/Abstract

摘要： 散乱蛋白(Dvl)是广泛存在于人体组织内的一种蛋白,含有三个结构域：散乱蛋白轴蛋白(DIX)结构域、突触后密集区蛋白-95/大型肿瘤抑制基因/紧密连接跨膜蛋白(PDZ)结构域、散乱蛋白/Egl-10/普列克底物蛋白(DEP)结构域。散乱蛋白通过不同的结构域参与Wnt信号传导,影响神经系统发育与神经损伤后神经发生。

关键词: 散乱蛋白, Wnt信号, 神经发生, 综述

Abstract: Dishevelled (Dvl) is a kind of protein widely existing in human tissue, containing three structural domains: Dishevelled and Axin (DIX); postsynaptic density protein-95, disc large tumour suppressor, zonula occludens-1 (PDZ); and Dishevelled, Egl-10 and pleckstrin (DEP). Dvl participates in the Wnt signaling through different structure domains to play a role in nervous system development and neurogenesis after nerve injury.

Key words: Dishevelled, Wnt signaling, neurogenesis, review

中图分类号:

R741

王志敏, 梅彩琴. 散乱蛋白对神经发生影响的研究进展[J]. 《中国康复理论与实践》, 2017, 23(5): 548-552.

WANG Zhi-min, MEI Cai-qin. Role of Dishevelled in Neurogenesis (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2017, 23(5): 548-552.

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