臭氧氧化与缺血再灌注损伤的研究进展

doi:10.3969/j.issn.1006-9771.2016.12.012

摘要/Abstract

摘要： 臭氧作为一种活性氧，具有诱导氧化应激作用，而小剂量臭氧预处理可使机体产生氧化耐受，甚至抗氧化损伤作用，从而保护器官缺血再灌注损伤。本文综述了臭氧预处理在心脏、肾脏、肝脏、骨骼肌、性腺及脑等器官缺血再灌注的研究现状，认为臭氧治疗在器官移植和心脑血管病具有潜在应用价值。同时，就近10年臭氧大自血疗法在缺血性脑血管病的临床应用是否合理的问题，提出疑问和思考。

关键词: 臭氧氧化, 缺血再灌注损伤, 缺血性脑血管病, 综述

Abstract: As an active oxygen, ozone can induce oxidative stress, however, small doses of ozone pretreatment of the body may develop to oxidation toleration, even anti-oxidative damage, thereby protecting organ from ischemia-reperfusion injury. This paper reviewed the status of ozone pretreatment in organ ischemia-reperfusion, such as heart, kidney, liver, skeletal muscle, gonads and brain. Ozone therapy may have potential application values in organ transplants and cardiovascular diseases. Meanwhile, whether clinical application of ozone big autohemotherapy in ischemic cerebrovascular disease is reasonable or not in nearly 10 years was put forward.

Key words: ozone oxidation, ischemia-reperfusion injury, ischemic cerebrovascular disease, review

中图分类号:

R364.1

陶希，黄靓，蔡华安，邓景贵. 臭氧氧化与缺血再灌注损伤的研究进展[J]. 《中国康复理论与实践》, 2016, 22(12): 1420-1419.

TAO Xi, HUANG Liang, CAI Hua-an, DENG Jing-gui. Research Progress of Ozone Oxidation and Ischemia-reperfusion Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2016, 22(12): 1420-1419.

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