《中国康复理论与实践》

《中国康复理论与实践》

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Notch信号通路在中枢神经系统神经发生过程中作用的研究进展①

邹礼梁，王奎，满夏楠，陈健尔   

  1. 浙江中医药大学，浙江杭州市310053。
  • 出版日期:2016-11-25 发布日期:2016-12-05

Role of Notch Signaling Pathway in Neurogenesis in Central Nervous System (review)

ZOU Li-liang, WANG Kui, MAN Xia-nan, CHEN Jian-er   

  1. Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
  • Published:2016-11-25 Online:2016-12-05

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摘要： Notch 信号通路是神经发育过程中必不可少的信号通路之一。它在胚胎生长发育期通过促进神经干细胞增殖或允许神经干细胞分化为神经元/胶质细胞，维持神经元和胶质细胞合适的数量和比例；在成年中枢神经系统损伤后，调控神经干/祖细胞向神经元/胶质细胞分化，参与和调控神经系统的修复过程。

关键词: Notch, 信号通路, 中枢神经系统, 神经发生, 神经干细胞, 神经祖细胞, 综述

Abstract: The Notch signaling pathway plays a pivotal role in the process of neurogenesis in central nervous system. It not only maintains the appropriate number and proportion of neurons and glial cells in the growth and development of embryo, but also regulates the injured neural stem/progenitor cells to differentiate into neurons/glial cells of the adult nervous system, promoting the repair of the nervous system.

Key words: Notch, signaling pathway, central nervous system, neurogenesis, neural stem cell, neural progenitor cell, review