《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (12): 1443-1446.

• 国际会议报道 • 上一篇    下一篇

体感诱发电位应用于Tourette综合征的临床探讨

杨从敏 1，程泓 2，李柄佑 1，王正 1，金荣疆 3，杨馨 3
  

  1. 1.成都中医药大学针灸推拿学院康复教研室，四川成都市 610075；2.成都中医药大学临床医学院，四川成都市610075；3.成都中医药大学针灸推拿学院/第三附属医院，四川成都市 610075。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-12-25 发布日期:2015-12-25

Clinical Study of Application of Somatosensory Evoked Potentials in Tourette Syndrome

YANG Cong-min1, CHENG Hong1, LI Bing-you1, WANG Zheng1, JIN Rong-jiang3, YANG Xin3
  

  1. 1. Teaching and Research Section of Rehabilitation, Acupuncture and Massage College, Chengdu University of TCM, Chengdu, Sichuan 610075, China; 2. Clinical Medical School, Chengdu University of TCM, Chengdu, Sichuan 610075, China; 3. Acupuncture and Massage College/the Third Affiliated Hospital, Chengdu University of TCM, Chengdu, Sichuan 610075, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-12-25 Online:2015-12-25

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摘要： 目的 基于体感诱发电位(SEP)评估感觉-运动皮层功能的理论，探讨 SEP评价 Tourette综合征的可行性。方法 选取2014年 3月~2015年 4月本院神经内科门诊符合纳入标准的 33例 Tourette综合征患儿作为试验组，另取 30名健康对照者作为正常组。两组均采用耶鲁综合抽动严重程度量表(YGTSS)进行评定，测量SEP。结果 两组SEP的N20峰潜伏期、峰-峰波幅无显著性差异(P>0.05)；试验组 P22峰潜伏期较正常组延长(t=2.356, P<0.05)，峰-峰波幅降低(t=2.507, P<0.05)；YGTSS评分较正常组明显升高(t=3.012, P<0.01)。SEP 的 P22峰潜伏期与 YGTSS 评分呈正相关(r=0.402, P<0.001)，P22波幅峰-峰波幅与 YGTSS 评分呈负相关(r=-0.180, P<0.001)。结论 Tourette综合征患儿存在皮质-纹状体-丘脑-皮质调节环路对感觉/运动冲动的抑制缺陷。可考虑将 SEP作为Tourette综合征患儿的客观检测指标。

关键词: Tourette综合征, 体感诱发电位, P22

Abstract: Objective To explore the feasibility of somatosensory evoked potentials (SEP) evaluating Tourette syndrome, based on the theory of SEP evaluating sensory-motor cortical function. Methods 33 cases of Tourette syndrome in our hospital from March 2014 to April 2015 were as the experiment group and 30 healthy participants were as the normal control group. Both groups were evaluated with Yale Global Tic Severity Scale (YGTSS) and SEP. Results There was no significant difference in N20 leak latency and leak-leak amplitude of SEP between 2 groups (P>0.05). The P22 leak latency prolonged (t=2.356, P<0.05) and the leak-leak amplitude decreased (t=2.507, P<0.05) in the experiment group compared with the normal control group. The YGTSS score was higher in the experiment group than in the normal control group (t=3.012, P<0.01). The P22 leak latency was positively (r=0.402, P<0.001), and the P22 leak-leak amplitude was negatively (r=-0.180, P<0.001) correlated with YGTSS score. Conclusion Children with Tourette syndrome are disordered in inhibiting sensory or motor impulse through cortex-striatum-thalamus-cortex regulation circuit. SEP is considered as the objective indicator of patients with Tourette syndrome.

Key words: Tourette syndrome, somatosensory evoked potentials, P22