《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (09): 1091-1094.

• 基础研究 • 上一篇    下一篇

PSMA6基因rs17458312位点多态性与脑梗死的相关性研究

赵西耀 1，何芳梅 2
  

  1. 作者单位：1.浙江大学医学院附属第二医院建德分院神经内科，浙江建德市 311600；2.西安医学院第一附属医院神经内科，陕西西安市710077。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-09-25 发布日期:2015-09-25

Association of rs17458312 Polymorphism of PSMA6 Gene with Cerebral Infarction

ZHAO Xi-yao1, HE Fang-mei2
  

  1. 1. Department of Neurology, the Second Affiliated Hospital (Jiande Branch), School of Medicine, Zhejiang University, Jiande, Zhejiang 311600, China; 2. Department of Neurology, the First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-09-25 Online:2015-09-25

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被引次数

3

摘要： 目的 探讨中国汉族人群中PSMA6基因rs17458312(-1520C/T)位点的多态性与脑梗死的相关性。方法 对211例脑梗死患者(病例组)和 201 例健康体检者(对照组)，应用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)检测 PSMA6 基因rs17458312位点单核苷酸多态性，并分析其基因型及等位基因频数的分布。结果 CC、CT、TT基因型频率及 C等位基因频率在两组中分布无显著性差异(P>0.05)。性别分层后，各亚组各基因型及等位基因频率分布也无显著性差异(P>0.05)。结论 PSMA6基因rs17458312位点可能与脑梗死的发病无关。

关键词: PSMA6基因, 单核苷酸多态性, 脑梗死

Abstract: Objective To evaluate the association between rs17458312 (-1520C/T) polymorphism of PSMA6 gene and cerebral infarction in Chinese Han population. Methods 211 cerebral infarction patients (case group) and 201 healthy controls (control group) were selected in the study. The single nucleotide polymorphism of rs17458312 of PSMA6 gene was identified with the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The genotypes and allele frequencies distributed in cerebral infarction patients and healthy controls were analyzed. Results The frequencies of CC, CT, TT genotypes and the C allele all revealed no significant difference between the case group and the control group (P>0.05). After stratified by genders, the difference among all genetypes and alleles weren't significant between subgroup (P>0.05). Conclusion The rs17458312 of PSMA6 gene might not be associated with the cerebral infarction.

Key words: PSMA6 gene, single nucleotide polymorphism, cerebral infarction