《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (08): 917-920.

• 特稿 • 上一篇    下一篇

Duchenne型肌营养不良携带者心脏损伤评估方法的研究进展

贾梦芸，吴士文   

  1. 安徽医科大学武警总医院临床学院，北京市100039。作者简介：贾梦芸(1991-)，女，汉族，安徽六安市人，硕士研究生，主要研究方向：神经肌肉病。通讯作者：吴士文。E-mail: neurowu@gmail.com。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-08-25 发布日期:2015-08-25

Progress of Cardiac Damage Assessment in Carriers of Duchenne Muscular Dystrophy (review)

JIA Meng-yun, WU Shi-wen   

  1. Clinical College of General Hospital of Armed Police Force, Anhui Medical University, Beijing 100039, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-08-25 Online:2015-08-25

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摘要： Duchenne 型肌营养不良(DMD)是一种X染色体连锁隐性遗传性神经肌肉病。DMD基因携带者可在没有肌无力情况下出现心脏损伤，甚至危及生命。早期发现心肌损害，并提前预防可以改变生活质量，降低死亡率。DMD基因携带者心脏损害的早期检查手段包括心电图、心脏超声、心血管磁共振成像、放射性核素心肌灌注显像及冠状血管造影术等。不同检查手段从不同角度评估DMD基因携带者心脏损伤情况。

关键词: Duchenne型肌营养不良, 心肌病, 携带者, 综述

Abstract: Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disorder, and the carriers of DMD can suffer from cardiac damage without muscle weakness, which can predispose to death. Consequently detecting and preventing cardiac damage in the early stage can improve the carriers' quality of life. The detection of early cardiac abnormalities and the evaluation of cardiac function for carriers mainly rely on the different examination methods, including electrocardiogram, echocardiogram, cardiovascular magnetic resonance, radioactive nuclide myocardial perfusion imaging and coronary angiography. Carriers of DMD with cardiac damage are assessed by different examination methods in different ways.

Key words: Duchenne muscular dystrophy, cardiomyopathy, carrier, review