《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (07): 838-840.

• 特稿 • 上一篇    下一篇

无骨折脱位型颈脊髓损伤患者颈髓的弥散张量成像

赵鹏 1a，陈学明 1a，刘亚东 1a，彭如臣 1b，张殿平 1b   

  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-07-25 发布日期:2015-07-25

Diffusion Tensor Imaging Study on Cervical Spinal Cord Injury without Radiographic Abnormality

ZHAO Peng1a, CHEN Xue-ming1a, LIU Ya-dong1a, PENG Ru-chen1b, ZHANG Dian-ping1b   

  1. 1. a. Department of Spine Surgery, b. Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-07-25 Online:2015-07-25

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被引次数

7

摘要： 目的 探讨应用磁共振弥散张量成像(DTI)定量分析无骨折脱位型颈脊髓损伤患者的可行性。方法 对15例无骨折脱位型颈脊髓损伤患者(患者组)和 20 例健康志愿者(对照组)行常规 MRI 和 DTI 扫描，分别测量各向异性分数(FA)和表观弥散系数(ADC)。结果 患者组FA为(0.475±0.109)，ADC为(1.438±0.252)×10-3 mm2/s。对照组FA为(0.604±0.096)，ADC值为(1.371±0.280)×10-3 mm2/s。与对照组相比，患者组FA降低(P<0.05)，ADC无显著性差异(P=0.267)。纤维束示踪成像(FT)显示，患者组颈髓白质纤维束不同程度受压凹陷、扭曲、减少、稀疏甚至断裂。结论 DTI能够敏感地发现无骨折脱位型颈脊髓损伤，FT能直观显示颈髓白质纤维束的细微损伤，为颈髓损伤程度的临床评估提供客观依据。

关键词: 无骨折脱位型颈脊髓损伤, 弥散张量成像, 各向异性分数, 表观弥散系数, 纤维束示踪成像

Abstract: Objective To apply MR diffusion tensor imaging (DTI) to quantitatively analyze cervical spinal cord injury without radiographic abnormality (CSCIWORA). Methods 15 patients with CSCIWORA and 20 healthy controls were scanned with MRI of conventional scans and DTI. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured. Results FA and ADC of the patients were (0.475±0.109) and (1.438±0.252)×10-3 mm2/s, respectively. Whereas, they were (0.604±0.096) and (1.371±0.280)×10-3 mm2/s in the controls. Compared with the controls, the FA was less (P<0.05) in the patients, but the ADC was not significantly different (P=0.267). The fiber tracking (FT) showed the abnormality of white matter fiber tracts of cervical spinal cord in the patients. Conclusion DTI can detect the CSCIWORA, and FT can directly display the injuries of white matter fiber tracts of cervical spinal cord, which provide more information to evaluate the clinical severity of CSCIWORA.

Key words: cervical spinal cord injury without radiographic abnormality, diffusion tension imaging, fractional anisotropy, apparent diffusion coefficient, fiber tracking