《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (01): 69-073.

• 临床研究 • 上一篇    下一篇

颈椎病慢性疼痛患者的默认网络研究

张华1a，王昊1b，李多多1b，贾宝林1b，谭中建1c，陈红1b
   

  1. 1.北京中医药大学东直门医院，a.神经内科；b.推拿科；c.放射科，北京市100700。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-01-25 发布日期:2015-01-25

Default Mode Network Altered in Chronic Pain Caused by Cervical Spondylosis

ZHANG Hua, WANG Hao, LI Duo-duo, JIA Bao-lin,TAN Zhong-jian, CHEN Hong.
   

  1. Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-01-25 Online:2015-01-25

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被引次数

4

摘要： 目的研究颈椎病慢性疼痛患者静息态默认网络的变化。方法健康人8 名，患者10 例行功能磁共振成像检查。采用独立成分分析分离基于皮层的默认网络，采用基于支持向量机分类方法找出区别正常组和患者组的成分脑区。结果慢性疼痛患者默认网络多个脑区连接强度均与对照组有差异。结论颈椎病慢性疼痛患者的默认网络连接强度与正常人不同，可能与疼痛患者的感知觉加工、情绪和记忆功能变化相关。

关键词: 颈椎病, 慢性疼痛, 默认网络, 支持向量机, 独立成分分析

Abstract: Objective To explore the changes of resting state default mode network (DMN) in patients with chronic pain caused by cervical spondylosis (CPCS). Methods 8 healthy controls and 10 patients accepted functional MRI scanning. Surface based DMN was extracted with independent component analysis (ICA). The functional connectivity of the components of DMN were discriminated with support vector machine (SVM) algorithm from the patients to the controls. Results The DMN connectivity was different in the patients from the controls in some of the component areas. Conclusion DMN of CPCS patients is disorder in multiple brain areas, which may be involved with dysfunction of perception processing, emotion and memory.

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