《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (12): 1133-1139.

• 临床研究 • 上一篇    下一篇

脑白质疏松轻度认知功能障碍静息态默认网络研究

石庆丽1,2，毕延超3，陈伟康4，陈红燕5，杨志杰6，陈宏宝6，张玉梅1
   

  1. 1.首都医科大学附属北京天坛医院神经内科，国家神经系统疾病临床医学研究中心，北京脑重大疾病研究院脑卒中研究所，脑血管病转化医学北京市重点实验室，北京市100050；2.北京市平谷区医院神经内科，北京市101200；3.北京师范大学认知与学习国家重点实验室，北京市100875；4.温州医科大学附属丽水市人民医院神经内科，浙江丽水市323000；5.首都医科大学附属北京天坛医院影像中心，北京市100050；6.河北省香河县人民医院脑血管科，河北廊坊市065400。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-12-25 发布日期:2014-12-25

Resting-state Default Mode Network of Leukoaraiosis Patients with Mild Cognitive Impairment

SHI Qing-li, BI Yan-chao, CHEN Wei-kang, CHEN Hong-yan, YANG Zhi-jie, CHEN Hong-bao, ZHANG Yu-mei.
  

  1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-12-25 Online:2014-12-25

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摘要： 目的通过静息态功能磁共振成像(rs-fMRI)技术对脑白质疏松(LA)轻度认知障碍(MCI)患者脑默认网络进行分析。方法LA 患者31 例，临床痴呆评分(CDR) 0.5；年龄、性别和受教育程度匹配的正常对照组27 人，CDR 为0。对入组人群进行rs-fMRI 数据采集。使用SPM5 软件进行分析处理，使用fMRI 工具盒对预处理后的数据进行独立成分分析(ICA)，组间差异进行双样本t 检验。结果静息状态下，对照组默认网络包括扣带回后部/楔前叶，双侧额叶内侧，双侧颞中回，双侧顶下回、角回，双侧海马。MCI组默认网络激活区域同对照组一致；同对照组相比，MCI患者扣带回前部/左侧额叶内侧、右侧海马旁回/钩回、右侧颞下回、左侧额叶深部白质/尾状核头部激活减低，左侧尾状核/扣带回前部、左侧额叶、左侧颞上回/顶下回的激活升高。结论LA患者静息状态默认网络活动异常，可能与认知障碍的发生有关。

关键词: 脑白质疏松, 轻度认知障碍, 静息态功能磁共振, 默认网络

Abstract: Objective To study the default mode network (DMN) of mild cognitive impairment (MCI) related to leukoaraiosis (LA) with resting-state functional magnetic resonance imaging (rs-fMRI). Methods 31 LA patients (Clinical Dementia Rating of 0.5) and 27 normal controls (Clinical Dementia Rating of 0, and matched in age, gender and lever of education) were scanned with the rs-fMRI. The data was analyzed with SPM5 software, using independent component analysis. The differences between the both groups were compared with two-sample t-test. Results The DMN during resting-state of normal controls was posterior cingulate cortex/precuneus, bilateral medial frontal cortex, bilateral middle temporal gyrus, bilateral inferior parietal gyrus, angular gyrus, bilateral hippocampus. The DMN of MCI group was consistent with the normal controls, but the activation decreased in anterior cingulate cortex/left medial frontal lobe, right parahippcampus/ uncus, right inferior temporal gyrus, left deep frontal white matter/head of caudate nucleus; and increased in the left caudate nucleus/anterior cingulate cortex, left frontal lobe, and left superior temporal gyrus/inferior parietal gyrus. Conclusion Activation of resting-state functional network is disorder in LA, which may relate to cognitive impairment.

Key words: leukoaraiosis, mild cognitive impairment, resting-state functional magnetic resonance imaging, default mode network