《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (5): 417-419.

• 论文 • 上一篇    下一篇

A型肉毒毒素对脑性瘫痪患儿腘绳肌痉挛的疗效

刘建军，席冰玉，纪树荣，吴卫红，张雁，曾凡勇，李南玲   

  1. 1.首都医科大学康复医学院，北京市100068；2.中国康复研究中心北京博爱医院，北京市100068。
  • 收稿日期:2013-12-10 修回日期:2014-01-29 出版日期:2014-05-25 发布日期:2014-05-25

Effect of Botulinum Toxin Type A on Spastic Hamstring in Children with Cerebral Palsy

LIU Jian-jun, XI Bing-yu, JI Shu-rong, et al.   

  1. Capital Medical University School of Rehabilitation Medicine, Beijing Bo'ai Hospital, China Rehabilitation Research Centre, Beijing 100068, China
  • Received:2013-12-10 Revised:2014-01-29 Published:2014-05-25 Online:2014-05-25

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摘要： 目的观察A型肉毒毒素(BTX-A)注射缓解脑瘫患儿腘绳肌痉挛的疗效。方法39 例存在腘绳肌痉挛的脑瘫患儿分为对照组(n=20)和观察组(n=19)，对照组采用常规康复训练，观察组在常规康复训练的基础上予BTX-A局部注射。治疗前后采用改良Ashworth 量表(MAS)、粗大运动功能测试(GMFM-88)、膝关节屈曲角度进行评定。结果治疗6 周后，观察组患儿腘绳肌MAS评分、膝关节屈曲角度、GMFM-88 评分均较治疗前改善(P<0.05)，且均优于对照组(P<0.05)；对照组GMFM-88 较治疗前改善(P<
0.05)。结论BTX-A注射可以有效缓解脑瘫患儿腘绳肌痉挛，有助于纠正异常步态，提高患儿运动功能。

关键词: 脑性瘫痪, 痉挛, 腘绳肌, A型肉毒毒素, 步态分析, 粗大运动功能

Abstract: Objective To observe the effect of Botulinum toxin type A (BTX-A) injection on spastic hamstring in the children with cerebral palsy. Methods 39 cerebral palsy children with spastic hamstring were divided into control group (n=20) and experimental group (n=
19). The control group accepted physical therapy, while the experimental group accepted BTX-A injection in affected hamstring in addition.They were assessed with modified Ashworth Scale (MAS), Gross Motor Fucntion Measure (GMFM-88) and flexion angle of knee joints before and after treatment. Results The scores of MAS and GMFM-88, and flexion angle of knee joints improved significantly 6 weeks after treatment in the experimental group (P<0.05), and improved more than that in the control group (P<0.05). Only the score of GMFM-88 improved significantly in the control group (P<0.05). Conclusion BTX-A injection can relieve hamstring spasticity in children with cerebral palsy, which may be helpful to correct abnormal gait and improve the motor function.

Key words: cerebral palsy, spasticity, hamstring, Botulinum toxin type A, gait analysis, gross motor fucntion