《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (3): 230-232.

• 论文 • 上一篇    下一篇

莫诺苷对局灶性脑缺血再灌注大鼠模型红细胞压积的影响

艾厚喜，孙芳玲，王晓峰，李艳菲，张丽，陈乃宏，王文   

  1. 1.首都医科大学宣武医院药物研究室，教育部神经变性病学重点实验室，北京市老年病医疗研究中心，北京市100053；2.中国医学科学院药物研究所，北京市100050；3.河北北方学院，河北张家口市075000。
  • 收稿日期:2013-06-28 修回日期:2013-07-18 出版日期:2014-03-25 发布日期:2014-03-25
  • 通讯作者: 王文

Effect of Morroniside on Hematocrit Percentage in Rat of Focal Cerebral Ischemia/Reperfusion

AI Hou-xi, SUN Fang-ling, WANG Xiao-feng, et al.   

  1. Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • Received:2013-06-28 Revised:2013-07-18 Published:2014-03-25 Online:2014-03-25

PDF (PC)

被引次数

7

摘要： 目的研究莫诺苷对局灶性脑缺血再灌注(MCAO)大鼠红细胞压积(Hct)的影响。方法改良Longa 法制备大鼠MCAO模型，造模后分别给予莫诺苷小剂量(30 mg/kg, n=8)、中剂量(90 mg/kg, n=8)、大剂量(270 mg/kg, n=8)和阿司匹林(n=8)连续灌胃7 d，每天1 次。腹主动脉采血，全自动血样测试仪检测Hct。结果模型组大鼠Hct 较假手术组显著升高(P<0.001)；莫诺苷小、中、大剂量组和阿司匹林组的Hct均比模型组降低(P<0.05)。结论莫诺苷能显著性抑制局灶性脑缺血再灌注引起的Hct升高。

关键词: 莫诺苷, 局灶性脑缺血, 红细胞压积, 大鼠

Abstract: Objective To investigate the effect of morroniside on hematocrit percentage in a rat model of focal cerebral ischemia/reperfusion.Methods After the modified model induced with occlusion of middle cerebral artery (MCAO) with suture embolus, morroniside was administered intragastrically at the dose of 30 mg/kg (n=8), 90 mg/kg (n=8), and 270 mg/kg (n=8) once a day for 7 d. Acetyl salicylic acid (ASA) was used as positive drug (n=8). Hematocrit percentage was measured with automatic blood tester. Results Compared with the sham group, hematocrit percentage of the model group significantly increased (P<0.001), but increased less in those treated with morroniside and ASA (P<0.05). Conclusion Morroniside could inhibit the increase of hematocrit percentage in MCAO rats.

Key words: morroniside, focal cerebral ischemia, hematocrit percentage, rats