《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (07): 640-644.

• 论文 • 上一篇    下一篇

炎症在帕金森病中的作用

袁廷伟，孙芳玲，蒋莹，艾厚喜，张丽，王文，龚大春   

  1. 1.首都医科大学宣武医院药物研究室，北京市100053；2.三峡大学，湖北宜昌市443002。
  • 收稿日期:2012-09-19 修回日期:2012-10-13 出版日期:2013-07-25 发布日期:2013-07-25
  • 通讯作者: 王文

Inflammation in Parkinson's Disease (review)

YUAN Ting-wei, SUN Fang-ling, JIANG Ying, et al.   

  1. Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • Received:2012-09-19 Revised:2012-10-13 Published:2013-07-25 Online:2013-07-25

PDF (PC)

被引次数

14

摘要： 帕金森病是中老年人常见的神经变性疾病，以黑质致密部多巴胺能神经元进行性缺失、纹状体多巴胺水平降低为主要特点。中枢神经系统炎症和全身炎症都会导致多巴胺能神经元变性和死亡；抑制中枢神经炎症，靶向调节全身炎症、减轻外周损伤对大脑的影响，有助于缓解和阻止病情的发展，给帕金森病的预防和治疗提供新思路。

关键词: 帕金森病, 神经炎症, 全身炎症, 综述

Abstract: Parkinson's disease is a common progressive neurodegenerative disorder among old people, characterized by progressive loss of dopamine-producing neurons in the substantia nigra pars compacta and accordingly low level of dopamine in the nigrostriatal pathway.Neuroinflammation and even systemic inflammation have been suggested to be involved in the demise of dopaminergic neurons. Anti-inflammatory treatment could protect brain from inflammatory injury and prevent the progressive course of Parkinson's disease, which suggests a potential new strategy for Parkinson's disease treatment.

Key words: Parkinson's disease, neuroinflammation, systemic inflammation, review