《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (05): 469-471.

• 论文 • 上一篇    下一篇

A型肉毒毒素对脑卒中恢复期下肢痉挛的疗效观察

赖喜新，陈奕雄，刘初容，张新斐，曾盼坚，张永红   

  1. 1.广东三九脑科医院，a.神经康复科；b.康复训练中心，广东广州市510120。
  • 收稿日期:2012-10-17 修回日期:2012-12-10 出版日期:2013-05-25 发布日期:2013-05-25
  • 通讯作者: 陈奕雄

Effect of Botulinum Toxin Type A on Lower Limbs Spasticity after Stroke

LAI Xi-xin, CHEN Yi-xiong, LIU Chu-rong, et al.   

  1. Guangzhou 999 Brain Hospital, Guangzhou 510120, Guangdong, China
  • Received:2012-10-17 Revised:2012-12-10 Published:2013-05-25 Online:2013-05-25

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摘要： 目的研究A型肉毒毒素治疗脑卒中恢复期下肢痉挛的效果。方法将109 例脑卒中恢复期患者随机分为治疗组和对照组， 两组除予以常规治疗和康复训练外， 治疗组对痉挛肌肉加用A 型肉毒毒素注射。用改良Ashworth 痉挛量表(MAS)、Fugl-Meyer 运动功能评定量表(FMA)、Berg 平衡量表(BBS)于治疗前，治疗4 周、12 周后进行评价。结果治疗后各时间点，治疗组MAS、FMA、BBS 评分均较对照组改善(P<0.05)。结论局部A型肉毒毒素注射配合系统的康复训练能明显改善痉挛性下肢瘫痪的肌肉痉挛、运动功能和平衡能力。

关键词: 脑卒中, 下肢痉挛, 康复, A型肉毒毒素

Abstract: Objective To study the effect of Botulinum toxin type A (BTX-A) on lower limbs spasticity after stroke. Methods 109 convalescent patients after stroke were randomly divided into treatment group and the control group. All the patients accepted routine treatment and rehabilitation, the treatment group accepted BTX-A injected in spastic muscles in addition. They were assessed with Fugl-Meyer assessment (FMA), modified Ashworth scale (MAS), Berg Balance Scale (BBS) before, 4 weeks and 12 weeks after treatment. Results The scores of MAS, BBS and FMA improved more in the treatment group than in the control group (P<0.05) after treatment. Conclusion Combination of local BTX-A injection can significantly release the lower limbs spasticity, and improve the motor and balance ability for patients after stroke.

Key words: stroke, lower limb spasticity, rehabilitation, Botulinum toxin type A