《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (05): 457-460.

• 论文 • 上一篇    下一篇

端粒酶延缓椎间盘退变的研究进展

梁广胜，殷明，刘玉亮，何丁文   

  1. 南昌大学第二附属医院骨科，江西南昌市330006。
  • 收稿日期:2012-10-19 修回日期:2013-01-29 出版日期:2013-05-25 发布日期:2013-05-25
  • 通讯作者: 殷明

Intervertebral Disc Degeneration Delay by Telomerase (review)

LIANG Guang-sheng, YIN Ming, LIU Yu-liang, et al.   

  1. Department of Spine Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China
  • Received:2012-10-19 Revised:2013-01-29 Published:2013-05-25 Online:2013-05-25

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摘要： 端粒酶是由RNA模板和蛋白亚基构成的一种高度特异性的核糖核蛋白复合体。它能通过保持端粒长度的动态平衡和调节p53-p21-pRb 通路、p16Ink41-pRb 通路和Wnt/β-catenin 信号通路来延长椎间盘细胞的寿命和保持细胞功能，进而延缓或阻止椎间盘退变的进程。端粒酶能调节椎间盘细胞的衰老和凋亡，可望运用端粒酶基因对椎间盘退变进行预防和修复重建其结构。

关键词: 端粒酶, 椎间盘退变, 信号通路, 综述

Abstract: Telomerase, as a highly specific ribonucleoprotein, is composed by the RNA template and protein subunits. It can delay or prevent the process of disc degeneration by maintaining telomere length homeostasis as well as affecting the p53-p21-pRb pathway, p16Ink41-pRb pathway and Wnt/β-catenin signal pathway. Telomerase can regulate the senescence and apoptosis of intervertebral disc cell, expected to prevention and repair reconstruction of the structure by telomerase gene therapy of intervertebral disc degeneration.

Key words: telomerase, intervertebral disc degeneration, signaling pathway, review