《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (3): 235-238.

• 论文 • 上一篇    下一篇

胶质瘤中过氧化物酶体增殖物激活受体γ表达与预后的关系

周长胜，王进昆，王伟民，王崇谦，尚亚军，王波，牟临杰，张浩，苏稳，丁鹏   

  1. 昆明医科大学附属第一医院神经外科，云南昆明市650032。
  • 收稿日期:2012-09-11 修回日期:2012-10-16 出版日期:2013-03-25 发布日期:2013-03-25
  • 通讯作者: 丁鹏

Relationship between Expression of Peroxisome Proliferators-activated Receptors γ in Gliomas and Outcome of Patients

ZHOU Chang-sheng, WANG Jin-kun, WANG Wei-min, et al.   

  1. Department of Neurosurgery, First Hospital of Kunming Medical University, Kunming 650032, Yunnan, China
  • Received:2012-09-11 Revised:2012-10-16 Published:2013-03-25 Online:2013-03-25

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摘要： 目的探讨人脑胶质瘤组织中过氧化物酶体增殖物激活受体(PPAR)γ表达水平与患者临床病理特征及预后的关系。方法采用免疫组织化学法检测48 例人脑胶质瘤组织PPARγ的表达水平，Kaplan-Meier 生存曲线比较PPARγ高表达组与低表达组患者的无进展生存期及总生存期。结果PPARγ表达在Ⅰ~Ⅳ级胶质瘤组织中随肿瘤恶性程度增加而降低(P<0.01)，表达水平与病理级别呈负相关(r=-0.770, P<0.01)。高表达组和低表达组无进展生存期和总生存期均有非常显著性差异(P<0.01)。结论PPARγ表达与胶质瘤的恶性程度相关，可以为临床判断脑胶质瘤患者预后提供依据。

关键词: 神经胶质瘤, 过氧化物酶体增殖物激活受体γ, 免疫组织化学, 预后

Abstract: Objective To explore the relationship among expression of peroxisome proliferators-activated receptors γ (PPARγ) in human glioma, malignancy and outcome. Methods The level of PPARγ was detected with immunohistochemistry in the glioma from 48 cases with glioma. The progression-free survival and overall survival were compared with Kaplan-Meier survival curve between the patients with more expression of PPARγ and less ones. Results The expression of PPARγ decreased (P<0.01) with the the tumor malignancy increasing from grade I to IV, which was negatively correlated (r=-0.770, P<0.01). Both the progression-free and overall survival time were significant difference between the patients with more expression of PPARγ and less ones (P<0.01). Conclusion PPARγ expression correlates with the malignancy of human glioma, which may predict the outcome of the patients.

Key words: glioma, peroxisome proliferators-activated receptors γ, immunohistochemistry, outcome