《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (3): 204-209.

• 论文 • 上一篇    下一篇

巴曲酶治疗急性脑梗死临床疗效的Meta 分析

程记伟，白宇，张晓菁，候郁青，张利军，陈学芬   

  1. 1.上海中医药大学附属普陀医院神经内科，上海市200062；2.上海中医药大学预防医学与卫生统计教研室，上海市201203。
  • 收稿日期:2012-12-26 修回日期:2013-02-16 出版日期:2013-03-25 发布日期:2013-03-25
  • 通讯作者: 白宇

Effects of Batroxobin on Acute Cerebral Infarction: A Meta-analysis

CHENG Ji-wei, BAI Yu, ZHANG Xiao-jing, et al.   

  1. Department of Neurology, Putuo Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
  • Received:2012-12-26 Revised:2013-02-16 Published:2013-03-25 Online:2013-03-25

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摘要： 目的评价巴曲酶治疗急性脑梗死的临床疗效。方法检索有关巴曲酶治疗急性脑梗死的随机对照研究文献。采用
Jadad 评分评价纳入文献质量。采用RevMan 4.2 软件进行Meta 分析。结果共有38 项研究纳入分析，其中阴性对照29 篇，降纤酶
对照6 篇，尿激酶对照3 篇。巴曲酶在有效率、降低神经功能缺损评分、降低纤维蛋白原方面优于阴性对照组(P<0.05)，在神经功
能缺损评分方面与尿激酶无显著性差异(P>0.05)，在有效率方面与降纤酶无显著性差异(P>0.05)。结论巴曲酶可改善急性脑梗死
患者神经功能缺损评分，降低纤维蛋白原水平。

关键词: 急性脑梗死, 巴曲酶, Meta 分析, 神经功能, 纤维蛋白原

Abstract: Objective To assess the clinical effect of Batroxobin on acute cerebral infarction. Methods Randomized controlled trials (RCTs) about Batroxobin used for acute cerebral infarction were recalled. The quality of the document were assessed with Jadad scale, and the RevMan 4.3 software was used for Meta-analysis. Results 38 RCTs were recalled. 29 trials were negatively controlled, 6 controlled with Defibrase, and 3 controlled with Urokinase. Batroxobin is more effective than negative controls on neurological function score and fibrinogen (P<0.05). There was no statistics difference between Batroxobin and Urokinase on the neurological function score (P>0.05), as well as incidence of improvement between Batroxobin and Defibrase (P>0.05). Conclusion Batroxobin can effectively improve the neurological function and reduce the fibrinogen for acute cerebral infarction.

Key words: acute cerebral infarction, Batroxobin, Meta-analysis, neurological function, fibrinogen