《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (2): 129-131.

• 论文 • 上一篇    下一篇

过表达肌浆网Ca2+-ATP酶对慢性心力衰竭犬神经内分泌系统的影响

付治卿，李小鹰，鲁晓春，米亚非，周声安   

  1. 解放军总医院南楼心血管一科，北京市100853。
  • 收稿日期:2012-07-20 修回日期:2012-08-29 出版日期:2013-02-25 发布日期:2013-02-25
  • 通讯作者: 李小鹰

Effect of Sarcoplasmic Reticulum Ca2 +-ATPase Overexpression on Neuroendocrine System in Chronic Heart Failure Beagles

FU Zhi-qing, LI Xiao-ying, LU Xiao-chun, et al.   

  1. First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China
  • Received:2012-07-20 Revised:2012-08-29 Published:2013-02-25 Online:2013-02-25

PDF (PC)

摘要： 目的研究心肌过表达肌浆网Ca2+-ATP酶(SERCA2a)基因对慢性心力衰竭犬神经内分泌系统的影响。方法超声心动图检测SERCA2a 基因转导对慢性心力衰竭犬心脏收缩功能的影响，放射免疫法测定血管紧张素Ⅱ与心房利钠肽、内皮素-1、肿瘤坏死因子-α、白介素-6 等神经内分泌因子。结果SERCA2a 基因转导后心力衰竭犬的心脏收缩功能得到改善(P<0.05)，同时上述神经内分泌因子水平均减低(P<0.05)。结论SERCA2a 过表达能改善心肌收缩功能，阻断神经内分泌系统的恶性循环，可能阻止或逆转心肌重塑。

关键词: 慢性心力衰竭, 肌浆网Ca2+-ATP酶, 过表达, 神经内分泌系统

Abstract: Objective To explore the effect of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) overexpression on neuroendocrine system in chronic heart failure beagles. Methods The cardiac contraction function of chronic heart failure beagles were assessed by echocardiography before and after SERCA2a gene transduction. Radiation immune method was used to test the serum level of neuroendocrine factors such as Angiotensin Ⅱ, atrial natriuretic peptide, endothelin-1 and TNF-α, IL-6. Results The cardiac contraction function of chronic heart failure beagles improved greatly (P<0.05), and the serum levels of neuroendocrine factors significantly reduced after SERCA2a overexpression (P<0.05). Conclusion The vicious circle of neuroendocrine system may be blocked partially by SERCA2a overexpression.

Key words: chronic heart failure, sarcoplasmic reticulum Ca2+-ATPase, overexpression, neuroendocrine system