《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (11): 1080-1081.

• 论文 • 上一篇    下一篇

联合用药治疗脊髓损伤中重度痉挛的临床观察

刘根林，周红俊，李建军，郑樱，郝春霞，张缨，卫波，王一吉，康海琼，汪家琮   

  1. 1.首都医科大学康复医学院，北京市100068；2.中国康复研究中心北京博爱医院，北京市100068。
  • 收稿日期:2012-07-02 修回日期:2012-07-06 出版日期:2012-11-25 发布日期:2012-11-25

Effect of Combination of Baclofen, Tizanidine and Eperisone on Moderate to Severe Spasticity after Spinal Cord Injury

LIU Gen-lin, ZHOU Hong-jun, LI Jian-jun, et al.   

  1. Capital Medical University School of Rehabilitation Medicine, Beijing Bo'ai Hospital, China Rehabilitation Research Centre, Beijing 100068, China
  • Received:2012-07-02 Revised:2012-07-06 Published:2012-11-25 Online:2012-11-25

PDF (PC)

被引次数

12

摘要： 目的观察联合应用巴氯芬、替扎尼定和乙哌立松治疗脊髓损伤中重度痉挛患者的临床效果。方法住院脊髓损伤中重度痉挛患者18 例，采用2 种或3 种药物联合应用，所有患者连续服药2 个月，并随访4 个月以上。采用改良Ashworth 评分进行评定，同时观察痉挛缓解持续时间及血压、血尿常规和肝肾功能。结果重度痉挛患者16 例中，3 例改良Ashworth 评分降低3 级，12 例降低2 级，1 例降低1 级，伴神经痛明显减轻；2 例中度痉挛患者均降低1 级，伴神经痛明显减轻。服药后肝肾功能未见异常，出现轻度嗜睡2 例。结论联合用药对脊髓损伤中重度痉挛患者的解痉效果明显，副作用小。

关键词: 脊髓损伤, 痉挛, 巴氯芬, 替扎尼定, 乙哌立松, 康复

Abstract: Objective To investigate the effect of combination of baclofen, tizanidine and eperisone on moderate or severe spasticity after spinal cord injury. Methods 18 inpatients with moderate (n=2) or severe (n=16) spasticity after spinal cord injury were treated with combination of 2 or 3 kinds of drugs for 2 months, and followed up for at least 4 months with modified Ashworth scale (MAS). Their blood pressure, blood and urine routine, liver and kidney function were observed. Results Among the 16 cases of severe spasticity (MAS≥3), MAS reduced 3 grades in 3 cases, 2 grades in 12 cases, 1 grade in 1 case, with alleviation of phantom pain. For the cases of moderate spasticity (MAS=2), the MAS reduced 1 grade with alleviation of phantom pain. Slightly drowsiness was observed in 2 cases. No hepatic or renal dysfunctions was found. Conclusion Combination of baclofen, tizanidine and eperisone is effective on moderate or severe spasticity after spinal cord injury with limited side-effects.

Key words: spinal cord injury, spasticity, baclofen, tizanidine, eperisone, rehabilitation