《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (12): 1131-1134.

• 论文 • 上一篇    下一篇

摄氧效率斜率评价慢性阻塞性肺疾病患者心肺功能的价值

赵红梅，汲阳，林亚静   

  1. 1.中国康复研究中心北京博爱医院呼吸内科，北京市100068；2.首都医科大学康复医学院，北京市100068。
  • 收稿日期:2012-09-10 修回日期:2012-10-02 出版日期:2012-12-25 发布日期:2012-12-25

Assessment of Oxygen Uptake Efficiency Slope on Cardiopulmonary Functional Reserve for Patients with Chronic Obstructive Pulmonary Disease

ZHAO Hong-mei, JI Yang, LIN Ya-jing.   

  1. Department of Respiratory, Capital Medical University School of Rehabilitation Medicine, Beijing Bo'ai Hospital, China Rehabilitation Research Centre, Beijing 100068, China
  • Received:2012-09-10 Revised:2012-10-02 Published:2012-12-25 Online:2012-12-25

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摘要： 目的探讨摄氧效率斜率(OUES)评价慢性阻塞性肺疾病(COPD)患者心肺功能的价值。方法对54 例肺功能Ⅱ~Ⅳ级的稳定期COPD患者进行运动心肺功能的评价，采用症状限制性Steep 分级平板运动方案，同时测定摄氧量(VO2)、二氧化碳排出量(VCO2)、峰值摄氧量(VO2peak)、每分通气量(VE)、呼吸气体交换率(RER)。采用对数曲线拟合的方法，分析递增负荷运动试验中VO2与VE之间的关系，建立回归方程VO2=algVE+b，计算摄氧效率斜率(OUES)，即a。同时测定无氧阈(VAT)。结果OUES与VO2peak呈显著正相关(均P<0.001)。75% OUES、90% OUES、100% OUES三者均值无显著性差异(F=0.239, P=0.830)。结论OUES可以反映COPD患者运动心肺功能，75% OUES可以作为亚极量运动水平心肺功能的评价指标。

关键词: 慢性阻塞性肺疾病, 摄氧效率斜率, 肺康复, 心肺功能

Abstract: Objective To investigate the efficacy of oxygen uptake efficiency slope (OUES) on evaluation the cardiopulmonary function of patients with chronic obstructive pulmonary disease (COPD). Methods The cardiopulmonary function of 54 stable COPD patients with the cardiopulmonary function of Ⅱ~Ⅳ were evaluated, following a symptom-limited Steep protocol with simultaneous respiratory gas measurement,they were performed exercise tests on a treadmill, simultaneously the oxygen uptake (VO2), carbon dioxide production (VCO2),peak oxygen uptake (VO2peak), minute ventilation (VE), and respiratory gas exchange rate (RER) were measured. OUES was derived from the relation between VO2 and VE during incremental exercise and was determined by VO2=algVE+b, where a=OUES, to measure anaerobic threshold (VAT) meanwhile. Results OUES correlated with the VO2peak (P<0.001). 75% OUES, 90% OUES and 100% OUES were not significantly different (F=0.239, P=0.830). Conclusion OUES can respond the cardiopulmonary function in patients with COPD, 75% OUES from sub-maximal exercise can be an index for cardiopulmonary function.

Key words: chronic obstructive pulmonary disease, oxygen uptake efficiency slope, pulmonary rehabilitation, cardiopulmonary function