《中国康复理论与实践》

《中国康复理论与实践》 ›› 2012, Vol. 18 ›› Issue (10): 939-940.

• 论文 • 上一篇    下一篇

视神经脊髓炎的研究进展

谢圣瑞   

  1. 瑞金市人民医院神经内科，江西瑞金市342500
  • 收稿日期:2012-02-03 修回日期:2012-03-03 出版日期:2012-10-25 发布日期:2012-10-25

Neuromyelitis Optica (review)

XIE Sheng-rui   

  1. Department of Neurology, Ruijin People's Hospital, Ruijin 342500, Jiangxi, China
  • Received:2012-02-03 Revised:2012-03-03 Published:2012-10-25 Online:2012-10-25

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摘要： 视神经脊髓炎(NMO)是一种累及视神经和脊髓的脱髓鞘免疫性疾病。NMO区别于多发性硬化(MS)亚型的特异性标志物是NMO-IgG，即抗水通道蛋白4(AQP4)抗体。AQP4 主要分布于中枢神经系统，参与胶质细胞与脑脊液、血液之间水的调节。NMO-IgG与AQP4 结合激发免疫反应导致病灶中AQP4 蛋白显著减少甚至丧失是NMO病理机制。

关键词: 视神经脊髓炎, 水通道蛋白4, 视神经骨髓炎抗体, 综述

Abstract: Neuromyelitis optica (NMO) is a rare demyelinating disease, affecting selectively optic nerve and spinal cord. NMO-IgG, an auto-antibody against aquaporin-4 (AQP4), identifies NMO as a disease entity separating from a severe variant of multiple sclerosis (MS). AQP4 is particularly abundant on the central nervous system, and is involves in regulation of water among of glial cells, and the blood and cerebrospinal fluid. NMO-IgG can target the AQP4 and initiate immune response leading to AQP4 protein loss in lesions, which is the key pathological mechanism of NMO.

Key words: neuromyelitis optica, aquaporin-4, neuromyelitis optica-IgG, review