《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (5): 436-438.

• 论文 • 上一篇    下一篇

周围神经损伤后轴突再生的分子机制研究进展

高洁，刘良明，伍亚民   

  1. 第三军医大学大坪医院野战外科研究所, 创伤烧伤与复合伤国家重点实验室，重庆市 400042。
  • 收稿日期:2009-12-16 修回日期:2010-03-25 出版日期:2010-05-25 发布日期:2010-05-25
  • 通讯作者: 伍亚民

Molecular Mechanism of Axonal Regeneration in Injured Peripheral Nerve (review)

GAO Jie, LIU Liang-ming, WU Ya-min.   

  1. State Key Laboratory of Trauma, Burns and Combined Injury, Department 3, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
  • Received:2009-12-16 Revised:2010-03-25 Published:2010-05-25 Online:2010-05-25

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被引次数

33

摘要： 周围神经损伤通常伴随活跃的再生反应。本文就周围神经损伤后早期神经元胞体、神经纤维和微环境调控分子包括相应转录因子、炎性介质、神经营养因子等促神经再生的分子机制研究进展予以概述，旨在探讨有效促进周围神经损伤后再生的相关机制。

关键词: 神经再生, 生长锥, 细胞因子, 神经营养因子, 综述

Abstract: The injury of peripheral nerve is generally accompanied with active regeneration responses. This paper is to summarize the molecular mechanism to promote the nerve regeneration, including various reactions of the neuronal body, nerve fiber, and regulatory molecules in the microenvironment, such as transcription factors, inflammatory mediators, nerve growth factors, etc., aiming to investigate the possible mechanism in the nerve regeneration after injury.

Key words: nerve regeneration, axonal growth cone, cytokine, neurotrophic factors, review