《中国康复理论与实践》

《中国康复理论与实践》 ›› 2010, Vol. 16 ›› Issue (4): 374-376.

• 论文 • 上一篇    下一篇

药物配合康复训练治疗进展性脑梗死60例疗效观察

高淑凤，焦丽琴   

  1. 丰台区铁营医院神经内科，北京市 100078。
  • 收稿日期:2009-12-14 修回日期:2010-02-26 出版日期:2010-04-25 发布日期:2010-04-25

Effects of Drug Therapy and Rehabilitation Training on 60 Strokes with Progressive Cerebral Infraction

GAO Shu-feng, JIAO Li-qin.   

  1. Department of Neurology, Tieying Hospital, Beijing 100079, China
  • Received:2009-12-14 Revised:2010-02-26 Published:2010-04-25 Online:2010-04-25

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被引次数

14

摘要： 目的观察奥扎格雷钠联合低分子肝素钙配合康复训练治疗进展性脑梗死的临床疗效。方法选择发病6～48 h内的缺血性进展性脑梗死患者60例，分为观察组与对照组，每组各30例。观察组采用奥扎格雷钠80 mg加生理盐水250 ml静脉滴注，每12小时1次，14 d为1个疗程，加用低分肝素钙0-4 ml皮下注射，每间隔12小时皮下注射1次，连用7 d；对照组采用单纯给予奥扎格雷钠治疗，用法同观察组。两组基础治疗相同，并均进行综合康复治疗。治疗前及治疗后1周对两组患者的血小板计数、活化部分凝血酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(Fg)进行测定。比较两组的NIHSS评分。结果两组治疗后神经功能缺损程度评分均明显降低，观察组降低尤为明显，与对照组比较有显著性差异(P<0-01)；观察组临床显效率为86-7%，明显优于对照组的60-0%(P<0-01)。两组血小板计数、PT、APTT、Fg均在正常范围内，两组均无明显的不良反应。结论奥扎格雷钠联合低分子肝素钙配合康复训练治疗进展性脑梗死安全有效。

关键词: 进展性脑梗死, 奥扎格雷钠, 低分子肝素钙, 康复

Abstract: ObjectiveTo observe the effects and safety of combination of Ozagrel and low molecular weight heparin and rehabilitation training in the treatment of progressive cerebral infraction. Methods60 patients with progressive cerebral infraction were divided into the observation group and the control group with 30 patients in each group. 80 mg Ozagrel plus 250 ml normal saline infusion were used in the observation group, once every 12 hours, 14 days for a course of treatment, 0-4 ml low molecular weight heparin was used with subcutaneous injection every 12 hours interval time, 14 days for a course of treatment. But only Ozagrel was used in the control group. The same treatment was used in the two groups, all patients received routine rehabilitation training. Platelet and activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (Fg) were examined before and 14 days after treatment. The NIHSS score was assessed.ResultsAfter treatment, NIHSS score in both groups decreased significantly(P<0-01) while the observation group was significantly better than the control group (P<0-01). The efficiency of the observation group was 86-7%, the control group was 60-0%, the observation group was significantly higher than the control group(P<0-05). Platelet count, PT, APTT, and Fg of the two groups were in the normal range, and there was no obvious adverse reaction.ConclusionOzagrel and low molecular weight heparin and rehabilitation training is safe and effective in the treatment of progressive cerebral infraction.

Key words: progressive cerebral infraction, Ozagrel, low molecular weight heparin, rehabilitation