《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (12): 1058-1059.

• 基础研究 • 上一篇    下一篇

平衡训练对小鼠大脑皮质及平衡功能的影响

刘新1; 王超懿2; 王锐1; 于敏华1   

  1. 1.吉林大学中日联谊医院神经康复科,吉林长春市 130033;2.北京体育大学运动人体科学学院,北京市 100084
  • 收稿日期:2006-04-26 出版日期:2006-12-01 发布日期:2006-12-01

Effect of Balance Training on Cerebral Cortex and Balance Function of Mouse

LIU Xin, WANG Chao-yi, WANG Rui, et al   

  1. The Department of Neurology Rehabilitation, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China
  • Received:2006-04-26 Published:2006-12-01 Online:2006-12-01

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摘要： 目的观察平衡训练对小鼠大脑皮质及平衡功能的影响。方法将45只C57BL/6J雌性小鼠随机分为对照组、训练2周组和训练4周组各15只。复制一种新型的平衡训练模型,对小鼠进行平衡木测验评估,测定脑指数、大脑皮质中的脂质过氧化物丙二醛(MDA)的含量及超氧化物歧化酶(SOD)活性。结果训练4周组小鼠通过平衡木的“总时间”与对照组和训练2周组比较,明显缩短(P<0.01);与对照组比较,训练2周组小鼠脑指数增高(P<0.05),训练4周组明显增高(P<0.01);与对照组相比,训练4周组小鼠大脑皮质SOD活性明显增高(P<0.01),MDA含量降低(P<0.05)。结论平衡训练可以改善小鼠大脑的平衡功能,提高脑指数,降低大脑皮质脂质过氧化水平。

关键词: 小鼠, 平衡训练, 大脑皮质, 超氧化物歧化酶, 丙二醛

Abstract: Objective To observe the effect of balance training on cerebral cortex and balance function of mouse.Methods Forty-five C57BL/6J female mice were randomly divided into the control group, two-week training group and four-week training group with 15 animals in each group. An new model of balance function training was copied. The balance function, brain index, and the content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in the mouse cerebral cortex were tested after training.Results The total time passing balance beam of the four-week training group significantly shorten compared with the control group and two-week training group ( P<0.01). Compared with the control group, the brain index of two-week training group increased ( P<0.05), and four-week training group also increased significantly ( P<0.01). Compared with the control group, the SOD activity of cerebral cortex significantly increased (P<0.01), and MDA decreased ( P<0.05) in the four-week training group.Conclusion This new balance training can improve balance function, increase the brain index and decrease lipid peroxidation level in the cerebral cortex of the mice.

Key words: mouse, balance training, cerebral cortex, superoxide dismutase (SOD), malondialdehyde (MDA)