《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (12): 1017-1020.

• 专题　骨科康复 • 上一篇    下一篇

脊髓步行中枢模式发生器

张缨1 综述; 纪树荣1,2 审校   

  1. 1.首都医科大学康复医学院,北京市 100068;2.北京博爱医院,北京市 100068
  • 收稿日期:2006-07-26 出版日期:2006-12-01 发布日期:2006-12-01

Spinal Locomotor Pattern Generator (review)

ZHANG Ying, JI Shu-rong   

  1. The Faculty of Rehabilitation, Capital Medical University, Beijing 100068, China
  • Received:2006-07-26 Published:2006-12-01 Online:2006-12-01

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摘要： 一般认为,哺乳动物(包括人在内)都是通过脊髓步行中枢模式发生器(CPG)控制步行运动,而CPG网络的边界是灵活的,脊髓损伤后脊髓步行CPG可实现网络重组。研究显示,减重步行平板训练(BWSTT)可使脊髓横断猫完全恢复后肢步行能力;临床也发现,脊髓损伤患者可通过BWSTT提高步行能力,表明脊髓可能具有运动学习的能力。因此,如何利用脊髓步行CPG的神经可塑性,为脊髓损伤患者制定最佳的步行训练方案,是令人关注的问题。

关键词: 脊髓损伤, 步行, 中枢模式发生器, 综述

Abstract: It is generally accepted that locomotion in mammals, including humans, is based on the activity of neuronal circuits within the spinal cord (the central pattern generator, CPG). Recent studies indicate a plastic behavior of the spinal neuronal circuits following a spinal cord injuries (SCI). Studies have shown that body weight support treadmill training (BWSTT) is effective in restoring locomotor function in cats with a complete spinal lesion. It has become possible to regain some locomotor activity in patients with spinal cord injury through an intense training on BWSTT, as in cat. So, it is a staired problem how to take advantage of the plasticity of spinal locomotor pattern generator and design the gait training program for SCI patients.

Key words: spinal cord injuries, locomotion, central pattern generator, review