《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (11): 966-967.

• 综述 • 上一篇    下一篇

肝细胞生长因子在心血管疾病诊断及治疗中的应用

李萍; 杨庭树   

  1. 解放军总医院心内科,北京市 100853
  • 收稿日期:2006-04-28 出版日期:2006-11-01 发布日期:2006-11-01

Advances of Hepatocyte Growth Factor in Cardiology(review)

LI Ping, YANG Ting-shu   

  1. Department ofCardiology, GeneralHospital ofPLA, Beijing 100853, China
  • Received:2006-04-28 Published:2006-11-01 Online:2006-11-01

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摘要： 肝细胞生长因子是一个多效的间充质因子,可以调节细胞的生长、运动和形态,具有促进血管生成,保护血管内皮、心肌细胞和抑制细胞凋亡及氧化应激等多重作用。本文就其与各种心血管疾病之间的关系做一综述。

关键词: 肝细胞生长因子, 心肌细胞, 内皮细胞, 缺血性心脏病, 动脉粥样硬化, 高血压, 心脏移植, 心功能不全, 综述

Abstract: Hepatocyte growth factor(HGF) is a mesenchyme-derived pleiotropic factor which regulates cell growth,cell motility,and morphogenesis of various types of cells,and is thus considered a humoral mediator of epithelial-mesenchymal interactions responsible for angiogenesis,apoptosis and oxidative stress,etc.This article reviewed the relationships between HGF and cardiovascular diseases.

Key words: hepatocyte growth factor, cadiocyte, endotheliocyte, ischemic heart disease, atherosclerotic disease, hypertension, heart transplantation, cardiac insufficiency, review