《中国康复理论与实践》

《中国康复理论与实践》 ›› 2006, Vol. 12 ›› Issue (10): 905-907.

• 临床研究 • 上一篇    下一篇

老年原发性高血压患者β2肾上腺素受体基因Arg16Gly多态性研究

王娜; 王志   

  1. 北京博爱医院急诊科,北京市 100068
  • 收稿日期:2006-04-03 出版日期:2006-10-01 发布日期:2006-10-01

Study of β2-adrenergic Receptor Gene Arg16Gly Polymorphism in Elder Essential Hypertension

WANG Na, WANG Zhi   

  1. The Department of Emergency, Beijing Charity Hospital, Beijing 100068, China
  • Received:2006-04-03 Published:2006-10-01 Online:2006-10-01

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摘要： 目的探讨老年人(≥60岁)β2肾上腺素受体(β2-AR)基因Arg16Gly多态性与高血压病的关系。方法随机抽取115名无血缘关系的老年原发性高血压患者(EH)为病例组,150名无血缘关系的健康老年人为对照组,采用PCR扩增技术测定两组对象的β2-AR基因型。结果高血压组的Arg/Arg、Gly/Gly和Arg/Gly基因型频率分别为22.81%、53.51%和23.68%;对照组分别为27.33%、67.33%和5.33%,两组间有显著性差异(P<0.05)。Arg和Gly的等位基因频率高血压组为49.56%、50.44%;对照组为61.00%和39.00%,两组间亦有显著性差异(P<0.05),但两组的Arg/Gly多态性分布均符合Hardy-Weinberg定律。结论本研究对象的β2-AR基因多态性可能与原发性高血压有关。

关键词: 原发性高血压, β2肾上腺素受体, 基因多态性

Abstract: ObjectiveTo explore the relationship between β2-adrenergic receptor (β2-AR) gene Arg16Gly polymorphism and essential hypertension (EH) in elder (≥60 years old).Methods150 old healthy controls and 115 old patients with EH (all of them without kin relation) were selected to test genotype of β2-AR by the technique of polymerase chain reaction-restriction fragment length polymorphism (PCR-PFLP).ResultsThe frequencies of three genotypes (Arg/Arg, Arg/Gly and Gly/Gly) were 22.81%, 53.51% and 23.68% in the EH group and 27.33%, 67.33% and 5.33% in the controls respectively. The frequencies of Arg and Gly allele were 49.56 % and 50.44% in the EH group, and 61.00% and 39.00% in the controls. There was a significant difference in distribution of alleles/genotypes between EH group and controls ( P<0.05).Conclusionβ2-AR Arg16Gly gene polymorphism is possibly associated with hypertension in this study population.

Key words: essential hypertension, β2-adrenergic receptor, gene polymorphism